Noninvasive diagnosis of colorectal adenoma: The emerging potential of blood-based biomarkers

Table 1 Diagnostic potential of noncoding RNAs in blood for colorectal adenomas[18,19,21-23,25,26,31,34,77,83-92]

Ref.	Study type and population	Biomarkers	Grouped control	AUC	Sensitivity (%)	Specificity (%)
Min et al[23]	Prospective observational study; 24 CAA; 53 NC	EV-delivered 9 RNAs, 3 miRNAs, 4 mRNAs, 2 lncRNAs	CAA/NC	0.880
Shi et al[22]	Prospective observational study; 29 CRC; 24 CAA; 22 NC	EV-delivered miR-185-5p	CRC/CAA	0.700	75.86
			CAA/NC	0.737	65.52	81.82
Raut et al[21]	Retrospective observational study; 52 CRC; 100 CAA; 88 NAA; 173 NC	7 serum miRNAs, let-7 g-5p, miR-19a-3p, miR-23a-3p, miR-92a-3p, miR-144-5p, miR-21-5p, miR-27a-3p	CRC/CAA	0.380
			CAA/NAA	0.590
			NAA/NC	0.440
Zaki et al[19]	Prospective observational study; 54 CRC; 15 CRA; 15 NC	miR-92a	CRC/CRA	0.993	92.6	93.3
			CRA/NC	0.529	73.3	46.7
Qi et al[26]	Clinical experimental study; 80 CRC; 80 CRA	3 plasma circRNAs, hsa-circ-001978, hsa-circ-105039, hsa-circ-103627	CRC/CRA	0.966
Han et al[83]	Observational study; 81 CRC; 67 CRA	EV-delivered 3 miRNAs, miR-15b, miR-16, miR-21	CRC/CRA		85.19	82.09
Wang et al[84]	Case-control study and retrospective cohort study; 42 CRA; 36 NC	miR-1207-5p	CRA/NC	0.953	90.48	80.56
Pan and Miao[85]	Experimental study; 50 CAA; 50 NC	miR-592	CAA/NC	0.747	68.60	78.1
Li et al[25]	Retrospective observational study; 102 CRC; 30 CRA	CircPanel, hsa-circ-0001900, hsa-circ-0001178, hsa-circ-0005927	CRC/CRA	0.818	84.31	70.0
Xu et al[34]	Experimental study; 30 CRA; 42 NC	SNHG11, ZFAS1	CRA/NC	0.868
			CRA/NC	0.850
Wang et al[31]	Case-control study; 40 CRA; 40 NC	piR-020619, piR-020450, piR-020619 + piR-020450	CRA/NC	0.701	82.50	55.90
			CRA/NC	0.689	67.50	72.50
			CRA/NC	0.779	72.50	76.60
Marcuello et al[86]	Prospective observational study; 74 CAA; 80 NC	6 serum miRNAs, miR-15b-5p, miR-18a-5p, miR-29a-3p, miR-335-5p, miR-19a-3p, miR-19b-3p	CAA/NC	0.800	81	63
Liu et al[87]	Observational study and experimental study; 80 CRC; 50 CRA; 30 NC	miR-1290, miR-320d, miR-1290 + miR-320d	CRA/NC	0.780	75.53	87.41
			CRA/NC	0.740	79.64	71.55
			CRA/NC	0.820	77.46	88.69
Roberts et al[77]	Cross-sectional study; 7 CRA; 12 NC	2 small RNAs, a miR-335-5p isoform, an unannotated small RNA	CRA/NC	0.833
Uratani et al[88]	Retrospective observational study; 26 CRA; 47 NC	miR-21, miR-29a, miR-92a	CRA/NC	0.755	73.1	68.1
			CRA/NC	0.676	72.0	66.0
			CRA/NC	0.747	65.4	78.7
Carter et al[89]	Prospective observational study; 25 CRC; 25 CAA	4 plasma miRNAs, miR-29c, miR-122, miR-192, miR-374a	CRC/CAA	0.980	72.0-80.0	100
Zheng et al[90]	Prospective observational study; 117 CAC; 73 CRA; 102 NC	4 serum miRNAs, miR-19a-3p, miR-223-3p, miR-92a-3p, miR-422a	CAC/CRA	0.886
			CRA/NC	0.765
Wang et al[91]	Case-control study; 43 CAA; 58 NC	miR-601, miR-760, miR-601 + miR-760	CAA/NC	0.638	72.1	51.7
			CAA/NC	0.682	69.8	62.1
			CAA/NC	0.683	72.1	62.1
Kanaan et al[92]	Retrospective observational study; 45 CRC; 16 CRA; 26 NC	8 plasma miRNAs, miR-532-3p, miR-331, miR-195, miR-17, miR-142-3p, miR-15b, miR-532, miR-652. 5 plasma miRNAs, miR-331, miR-15b, miR-21, miR-142-3p, miR-339-3p	CRA/NC	0.868	88	64
			CRC/CRA	0.856	91	69
Huang et al[18]	Retrospective observational study; 37 CAA; 59 NC	miR-29a, miR-92a, miR-29a + miR-92a	CAA/NC	0.769	62.2	84.7
			CAA/NC	0.749	64.9	81.4
			CAA/NC	0.773	73.0	79.7

AUC: Area under the curve; CAA: Colorectal advanced adenoma; NC: Normal controls; CRC: Colorectal cancer; NAA: Nonadvanced colorectal adenoma; CRA: Colorectal adenoma; miRNA: MicroRNA; EV: Extracellular vesicle; lncRNA: Long noncoding RNA; mRNA: Messenger RNA; CAC: Colorectal adenocarcinoma.