Lactate metabolism-driven tumor heterogeneity and molecular signatures in intrahepatic cholangiocarcinoma

Figure 1 Single-cell landscape and cell-type annotation of intrahepatic cholangiocarcinoma. A: Uniform manifold approximation and projection (UMAP) projection identifying 31 transcriptionally distinct clusters; B: Cell-type annotation based on canonical marker gene expression, revealing 11 major populations; C: Dot-plot visualization of representative marker genes used for each annotated cell type and their relative expression level; D: UMAP feature plots showing spatial expression patterns of selected canonical markers. UMAP: Uniform manifold approximation and projection; NK: Natural killer; DC: Dendritic cell.