Gallbladder carcinoma in Brazil: Clinicopathological profile and survival outcomes from a high-volume cancer center

Table 1 Characteristics of gallbladder cancer patients according to the groups - incidental gallbladder cancer and non-incidental gallbladder cancer, n (%)

Variables	Total (n = 364)	IGBC (n = 197)	Non-IGBC (n = 167)	P value
Sex				0.627
Female	287 (78.8)	157 (79.7)	130 (77.8)
Male	77 (21.2)	40 (20.3)	37 (22.2)
Age (years), mean ± SD	62.1 ± 12.0	61.6 ± 12.2	62.8 ± 11.8	0.344
Body mass index (kg/m2), mean ± SD	25.8 ± 5.7	26.3 ± 5.8	25.3 ± 5.5	0.085
Δt diagnoses to therapeutic approach (months)				< 0.001
mean ± SD	4.0 ± 7.7	5.4 ± 10.1	2.4 ± 2.1
Median (IQR)	2.5 (1.5-4.1)	3.2 (2.0-5.1)	1.7 (1.1-2.8)
CEA, median (IQR)	4.2 (2.2-19.5)	3.4 (1.9-10.9)	5.7 (2.8-22.2)	0.047
CA 19-9, median (IQR)	499 (97-8347)	171 (60-1186)	2897 (230-20465)	< 0.001
ECOG performance status scale				< 0.001
ECOG 0/1/2	227 (63.1)	141 (71.9)	86 (52.4)
ECOG 3/4	133 (36.9)	55 (28.1)	78 (47.6)
Final approach				< 0.001
T1a (follow-up)	7 (1.9)	7 (3.6)	0 (0)
Curative surgery	49 (13.5)	32 (16.2)	17 (10.2)
Observation	29 (8.0)	29 (14.7)	0 (0)
Palliative	279 (76.6)	129 (65.5)	150 (89.8)
T				< 0.001
T1a	9 (2.5)	7 (3.6)	2 (1.2)
T1b	21 (5.8)	19 (9.6)	2 (1.2)
T2	80 (22.0)	72 (36.5)	7 (4.8)
T3	142 (39.0)	82 (41.6)	60 (35.9)
T4	112 (30.8)	17 (8.6)	95 (56.9)
N				< 0.001
N0	108 (29.7)	78 (39.6)	30 (18.0)
N+	256 (70.3)	119 (60.4)	137 (82.0)
M				< 0.001
M0	107 (29.4)	74 (37.6)	33 (19.8)
M1	257 (70.6)	123 (62.4)	134 (80.2)
TNM				< 0.001
I	22 (6.0)	19 (9.6)	3 (1.8)
II	29 (8.0)	24 (12.2)	5 (3.0)
III	30 (8.2)	21 (10.7)	9 (5.4)
IV	283 (77.7)	133 (67.5)	150 (89.8)
Mortality following diagnosis
30-day mortality	6 (1.6)	1 (0.5)	5 (3.0)	0.098
90-day mortality	48 (13.2)	13 (6.6)	35 (21.0)	< 0.001

IGBC: Incidental gallbladder cancer; IQR: Interquartile range; CEA: Carcinoembryonic antigen; CA 19-9: Carbohydrate antigen 19-9; ECOG: Eastern Cooperative Oncology Group; TNM: Tumor-node-metastasis; SD: Standard deviation.