Lack of follow-up in Helicobacter pylori eradication treatment: Results from the European registry on Helicobacter pylori management

doi:10.3748/wjg.v32.i7.113541

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 21, 2026; 32(7): 113541
Published online Feb 21, 2026. doi: 10.3748/wjg.v32.i7.113541

Table 4 Factors associated with non-retreatment of Helicobacter pylori after a therapeutic failure-multivariate analysis, n (%)

Variables	Retreatment (n = 5954)	Non-retreatment
		Overall (n = 950)			Medical perspective (n = 393)			Patient perspective (n = 474)
		n (%)	P value	OR (95%CI)	n (%)	P value	OR (95%CI)	n (%)	P value	OR (95%CI)
Sex
Male	2100 (35.3)	386 (40.6)	0.000	1.30 (1.12-1.50)	147 (37.4)	0.116		206 (43.5)	0.004	1.34 (1.10-1.63)
Female	3850 (64.7)	564 (59.4)			246 (62.6)			268 (56.5)
Age, years
18-70	5455 (91.6)	851 (89.5)	0.015	1.35 (1.06-1.72)	350 (89.1)	0.028	1.49 (1.04-2.13)	430 (90.7)	0.282
≥ 71	475 (7.9)	96 (10.1)			40 (10.2)			44 (9.3)
Reclassified indication¹
Highly recommended	1075 (18.1)	182 (19.2)	0.989		80 (20.4)	0.536		87 (18.4)	0.765
Poorly recommended	4879 (81.9)	768 (80.8)			313 (79.6)			387 (81.6)
Number of previous eradication attempts
One attempt	1054 (17.7)	181 (19.1)	0.000	1.57 (1.30-1.89)	82 (20.9)	0.000	2.07 (1.57-2.73)	82 (17.3)	0.109
Two attempts	334 (5.6)	105 (11.1)	0.000	2.82 (2.21-3.61)	61 (15.5)	0.000	4.89 (3.54-6.74)	26 (5.5)	0.006	1.69 (1.16-2.44)
Three attempts	115 (1.9)	63 (6.6)	0.000	5.05 (3.63-7.03)	39 (9.9)	0.000	9.25 (6.15-13.93)	21 (4.4)	0.000	2.91 (1.78-4.76)
Four attempts	42 (0.7)	27 (2.8)	0.000	6.00 (3.61-9.96)	12 (3.1)	0.000	7.84 (3.96-15.53)	10 (2.1)	0.000	3.60 (1.75-7.41)
Five attempts	28 (0.5)	13 (1.4)	0.000	4.04 (2.04-8.02)	5 (1.3)	0.002	4.73 (1.75-12.77)	5 (1.1)	0.073
Treatment compliance²	5647 (94.8)	739 (77.8)	0.000	6.07 (4.97-7.41)	303 (77.1)	0.000	4.27 (2.64-2.93)	358 (75.5)	0.000	10.04 (7.37-13.68)
Severe AE³	137 (2.3)	44 (4.6)	0.665		24 (6.1)	0.621		18 (3.8)	0.535
Serious AE⁴	9 (0.2)	5 (0.5)	0.642		5 (1.3)	0.261		NA	NA
Interruption by AE	183 (3.1)	109 (11.5)	0.053		68 (17.3)	0.010	2.06 (1.19-3.56)	39 (8.2)	0.000	0.34 (0.22-0.55)

¹Highly recommended: Preneoplastic lesions, personal history of gastric cancer with surgical and/or endoscopic resection, 1^st degree relatives of patients with gastric cancer, mucosa-associated lymphoid tissue lymphoma, and gastric or duodenal ulcers. Poorly recommended: Functional and uninvestigated dyspepsia, vitamin B12 deficiency, treatment with nonsteroidal anti-inflammatory drugs or acetylsalicylic acid, prolonged treatment with proton pump inhibitors, iron deficiency anemia, idiopathic thrombocytopenic purpura.

²Compliance: > 90% drug intake.

³Severe adverse event: Refers to the intensity of the symptoms.

⁴Serious adverse event: Unexpected medical occurrence, such as life-threatening, risk of hospitalization, or malformations.

AE: Adverse event; NA: Not appliable; OR: Odds ratio; CI: Confidence interval.

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Citation: Cantú-Germano E, Moreira L, Pérez-Aisa Á, Martínez-Domínguez SJ, Voynovan I, Bujanda L, Jonaitis L, Tepes B, Garre A, Lucendo AJ, Lerang F, Butler T, Mahmudov U, Huguet JM, Tejedor-Tejada J, Bogomolov P, Beales IL, Phull PS, Pabon-Carrasco M, Castro-Fernández M, Alekseenko S, Pavoni M, Zaytsev O, Bumane R, Denkovski M, Cajal MD, Tatiana I, Areia M, Keco-Huerga A, Babayeva G, Bermejo F, Simsek H, Buzás GM, Losurdo G, Bordin DS, Kupcinskas J, Smith SM, Gasbarrini A, Leja M, Marcos-Pinto R, Simsek C, Papp V, Rodríguez BJ, Mejide PP, Villarroya RP, Alonso MS, Cano-Català A, Megraud F, O’Morain C, Parra P, Nyssen OP, Gisbert JP. Lack of follow-up in Helicobacter pylori eradication treatment: Results from the European registry on Helicobacter pylori management. World J Gastroenterol 2026; 32(7): 113541
URL: https://www.wjgnet.com/1007-9327/full/v32/i7/113541.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i7.113541

Cantú-Germano E, Moreira L, Pérez-Aisa Á, Martínez-Domínguez SJ, Voynovan I, Bujanda L, Jonaitis L, Tepes B, Garre A, Lucendo AJ, Lerang F, Butler T, Mahmudov U, Huguet JM, Tejedor-Tejada J, Bogomolov P, Beales IL, Phull PS, Pabon-Carrasco M, Castro-Fernández M, Alekseenko S, Pavoni M, Zaytsev O, Bumane R, Denkovski M, Cajal MD, Tatiana I, Areia M, Keco-Huerga A, Babayeva G, Bermejo F, Simsek H, Buzás GM, Losurdo G, Bordin DS, Kupcinskas J, Smith SM, Gasbarrini A, Leja M, Marcos-Pinto R, Simsek C, Papp V, Rodríguez BJ, Mejide PP, Villarroya RP, Alonso MS, Cano-Català A, Megraud F, O’Morain C, Parra P, Nyssen OP, Gisbert JP. Lack of follow-up in Helicobacter pylori eradication treatment: Results from the European registry on Helicobacter pylori management. World J Gastroenterol 2026; 32(7): 113541 [PMID: 41694498 DOI: 10.3748/wjg.v32.i7.113541]

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