Twenty-year temporal trends, risk profiles, and prognostic value of clinicopathological features in gallbladder cancer following cholecystectomy

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 21, 2026; 32(7): 111478
Published online Feb 21, 2026. doi: 10.3748/wjg.v32.i7.111478

Table 4 Comparison of histopathologic features of gallbladder cancer according to tumor stage (n = 285), n (%)

Pathological features	Stage		P value
Pathological features	I & II (n = 187)	III & IV (n = 98)	P value
Preinvasive neoplasm			0.000
ICPN	70 (37.4)	15 (15.3)
BilIN or adenoma	117 (62.6)	83 (84.7)
Histologic cell differentiation			0.722
Pancreaticobiliary	147 (78.6)	79 (80.6)
Intestinal	40 (21.4)	19 (19.4)
Non-neoplastic change (hyperplasia or metaplasia)	152 (81.3)	80 (81.6)	0.943
Liver involvement	11 (5.9)	22 (22.4)	0.000
Poorly cohesive component (including signet ring cells)	38 (20.3)	42 (43.8)	0.000
Undifferentiated component (including squamous or sarcomatous)	29 (15.5)	26 (26.5)	0.025
Depth of invasion (cm)	0.38	0.88	0.000
Tumor size (cm)	0.83	1.93	0.000
Tumor budding (buds/0.785 mm²)	2.97	6.47	0.000

ICPN: Intracholecystic papillary neoplasm; BilIN: Biliary intraepithelial neoplasia.

Citation: An J, Ahn SH, Kim KH, Heo JY, Yeo MK. Twenty-year temporal trends, risk profiles, and prognostic value of clinicopathological features in gallbladder cancer following cholecystectomy. World J Gastroenterol 2026; 32(7): 111478
URL: https://www.wjgnet.com/1007-9327/full/v32/i7/111478.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i7.111478

An J, Ahn SH, Kim KH, Heo JY, Yeo MK. Twenty-year temporal trends, risk profiles, and prognostic value of clinicopathological features in gallbladder cancer following cholecystectomy. World J Gastroenterol 2026; 32(7): 111478 [PMID: 41694497 DOI: 10.3748/wjg.v32.i7.111478]

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