Psychological and hematological factors associated with fatigue in patients with Crohn’s disease receiving pharmacological treatment

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Feb 7, 2026; 32(5): 115673
Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.115673

Table 6 Assessment of fatigue with different laboratory parameters in patients with Crohn’s disease treated at a reference center

Laboratory parameter	Average (no fatigue)	Average (with fatigue)	P value	Cohen’s d
Erythrocytes (million/mm³)	4.7	4.61	0.432	0.23
Hemoglobin (g/dL)	13.59	13.22	0.199	0.38
Hematocrit (%)	40.29	39.19	0.252	0.32
RDW (%)	13.89	14.13	0.362	0.26
Total leukocytes (thousand/mm³)	6.140	7.052	0.034	0.39
Platelets (million/mm³)	278.12	283.53	0.726	0.07
Transferrin saturation index (%)	23.14	18.76	0.208	0.40
Ferritin (ng/mL)	130.70	144.35	0.742	0.09
Serum iron (μg/dL)	74.88	67.09	0.396	0.27
Vitamin B12 (pg/mL)	426.77	415.76	0.830	0.06
Vitamin B1 (ng/mL)	6.94	6.42	0.436	0.23
Free T4 (ng/dL)	1.13	1.10	0.525	0.18
Ultrasensitive TSH (μIU/mL)	2.16	1.79	0.186	0.39
CRP (mg/dL)	0.60	0.73	0.442	0.22
Erythrocyte sedimentation rate (mm/hour)	11.06	13.26	0.392	0.27

RDW: Red cell distribution width; TSH: Thyroid-stimulating hormone; CRP: C-reactive protein.

Citation: Morais TC, Couto G, Silva BCD, Lisbôa RA, da Cruz BS, Viana MGF, de Sousa GBC, Arenas LP, Nery ES, Fortes FML, de Almeida NP, Pimentel AM, Fontes JAM, Surlo VC, Chebli JF, Rocha R, Santana GO. Psychological and hematological factors associated with fatigue in patients with Crohn’s disease receiving pharmacological treatment. World J Gastroenterol 2026; 32(5): 115673
URL: https://www.wjgnet.com/1007-9327/full/v32/i5/115673.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i5.115673

Morais TC, Couto G, Silva BCD, Lisbôa RA, da Cruz BS, Viana MGF, de Sousa GBC, Arenas LP, Nery ES, Fortes FML, de Almeida NP, Pimentel AM, Fontes JAM, Surlo VC, Chebli JF, Rocha R, Santana GO. Psychological and hematological factors associated with fatigue in patients with Crohn’s disease receiving pharmacological treatment. World J Gastroenterol 2026; 32(5): 115673 [PMID: 41693975 DOI: 10.3748/wjg.v32.i5.115673]

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