ICAM2 loss drives 5-fluorouracil resistance via TGF-β/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer

doi:10.3748/wjg.v32.i5.115301

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 32, Issue 5

This Article

(54)

(59)

(1)

(0)

(1)

(11)

(1028)

(1)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Feb 7, 2026; 32(5): 115301
Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.115301

Table 2 Univariate and multivariate analyses of factors associated with overall and disease-free survival in advanced gastric cancer patients

Variables	OS (univariate analysis)			OS (multivariate analysis)			DFS (univariate analysis)			DFS (multivariate analysis)
Variables	HR	95%CI	P value	HR	95%CI	P value	HR	95%CI	P value	HR	95%CI	P value
ICAM2 in serum (high vs low)	0.378	0.202-0.707	0.002	0.441	0.234-0.828	0.011	0.403	0.222-0.730	0.003	0.446	0.245-0.811	0.008
Age (years; ≥ 60 vs < 60)	1.429	0.806-2.532	0.222				1.450	0.831-2.531	0.191
Gender (male vs female)	0.824	0.435-1.562	0.553				1.004	0.534-1.887	0.991
CEA (ng/mL; > 5 vs ≤ 5)	0.788	0.416-1.492	0.465				0.660	0.351-1.242	0.198
CA19-9 (U/mL; > 37 vs ≤ 37)	1.954	0.995-3.838	0.052				1.751	0.896-3.421	0.101
Differentiation (high and moderate vs poor)	0.588	0.323-1.067	0.081				0.688	0.388-1.221	0.201
Advanced TNM stage (III vs II)	3.298	1.763-6.170	< 0.001	2.938	1.562-5.528	0.001	3.226	1.776-5.860	< 0.001	2.977	1.644-5.462	< 0.001

OD: Overall survival; DFS: Disease-free survival; ICAM2: Intercellular adhesion molecule 2; CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen.

Full Size Table

Citation: Tang XC, Chen ZJ, Chen CY, Qiu J, Huang JT, Tan RC, Li WY, Chen H, Yang ZL. ICAM2 loss drives 5-fluorouracil resistance via TGF-β/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer. World J Gastroenterol 2026; 32(5): 115301
URL: https://www.wjgnet.com/1007-9327/full/v32/i5/115301.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i5.115301

Tang XC, Chen ZJ, Chen CY, Qiu J, Huang JT, Tan RC, Li WY, Chen H, Yang ZL. ICAM2 loss drives 5-fluorouracil resistance via TGF-β/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer. World J Gastroenterol 2026; 32(5): 115301 [PMID: 41693979 DOI: 10.3748/wjg.v32.i5.115301]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.