Identification of strong correlations of clearance with clinical outcomes for inflammatory bowel disease

doi:10.3748/wjg.v32.i5.113505

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 7, 2026; 32(5): 113505
Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.113505

Table 2 Initial infliximab clearance, probability of mucosal healing, probability of C-reactive protein normalization, and probability of antidrug antibody for patients who received Bayesian model-guided treatment

Patients	CL (L/day)	Probability of MHEAL	Probability of CRP normalization	Probability of ADA
1	0.6236	7.42	19.19	94.47
3	1.1102	0.73	3.95	100.00
4	0.3160	39.44	47.78	56.62
5	0.0168	73.32	70.22	18.14
6	0.2722	46.50	52.49	47.96
7	0.3937	28.18	39.42	71.38
8	0.6329	7.07	18.56	94.78
9	0.6095	7.94	20.15	93.99
11	0.4288	23.95	35.99	76.34
12	0.5125	14.82	28.13	86.66

ADA: Antidrug antibody; CL: Clearance; CRP: C-reactive protein; MHEAL: Mucosal healing.

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Citation: Mould DR, Kutschera M, Primas C, Reinisch S, Novacek G, Lichtenberger C, Dervieux T, Bae Y, Lee SH, Lee JH, Reinisch W. Identification of strong correlations of clearance with clinical outcomes for inflammatory bowel disease. World J Gastroenterol 2026; 32(5): 113505
URL: https://www.wjgnet.com/1007-9327/full/v32/i5/113505.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i5.113505

Mould DR, Kutschera M, Primas C, Reinisch S, Novacek G, Lichtenberger C, Dervieux T, Bae Y, Lee SH, Lee JH, Reinisch W. Identification of strong correlations of clearance with clinical outcomes for inflammatory bowel disease. World J Gastroenterol 2026; 32(5): 113505 [PMID: 41693973 DOI: 10.3748/wjg.v32.i5.113505]

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