Integrating proteomics, metabolomics, and molecular docking to elucidate the mechanism of Jiangtang Qingre formula against metabolic dysfunction-associated steatohepatitis

doi:10.3748/wjg.123033

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Dec 28, 2026; 32(48): 123033
Published online Dec 28, 2026. doi: 10.3748/wjg.123033

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Figure 5 Jiangtang Qingre formula modulates the hepatic metabolome in methionine-choline-deficient diet-induced metabolic dysfunction-associated steatohepatitis mice (n = 8). A: Partial least squares discrimination analysis score plots depicting group separation; B: Volcano plots of differential metabolites [methionine-choline-deficient (MCD) vs methionine-choline-sufficient; MCD + Jiangtang Qingre formula-high vs MCD]; C: Human metabolome database compound classification of the differential metabolites; D: Top 20 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways from the topological analysis of differential metabolites; E: Top 20 shared KEGG pathways enriched by differentially expressed proteins (DEPs) and differential metabolites; F: Correlation heatmap of the top 20 differential metabolites and metabolic dysfunction-associated steatohepatitis-related phenotypes; G: Correlation network of the 26 core DEPs and the 20 key differential metabolites. MCD: Methionine-choline-deficient; MCS: Methionine-choline-sufficient; JQFH: Jiangtang Qingre formula-high; KEGG: Kyoto Encyclopedia of Genes and Genomes.

Citation: Zhou LJ, Wu JL, Wang H, Han R, Tang C, Fang F, Zhu DP. Integrating proteomics, metabolomics, and molecular docking to elucidate the mechanism of Jiangtang Qingre formula against metabolic dysfunction-associated steatohepatitis. World J Gastroenterol 2026; 32(48): 123033
URL: https://www.wjgnet.com/1007-9327/full/v32/i48/123033.htm
DOI: https://dx.doi.org/10.3748/wjg.123033

Zhou LJ, Wu JL, Wang H, Han R, Tang C, Fang F, Zhu DP. Integrating proteomics, metabolomics, and molecular docking to elucidate the mechanism of Jiangtang Qingre formula against metabolic dysfunction-associated steatohepatitis. World J Gastroenterol 2026; 32(48): 123033 [DOI: 10.3748/wjg.123033]

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