Integrating proteomics, metabolomics, and molecular docking to elucidate the mechanism of Jiangtang Qingre formula against metabolic dysfunction-associated steatohepatitis

Figure 4 Jiangtang Qingre formula modulates the hepatic proteome in methionine-choline-deficient diet-induced metabolic dysfunction-associated steatohepatitis mice (n = 5). A: Volcano plots depicting differentially expressed proteins (DEPs) in the methionine-choline-deficient (MCD) vs methionine-choline-sufficient and MCD + Jiangtang Qingre formula-high vs MCD comparisons; B: Venn diagram of DEP overlap; C: Gene Ontology biological process enrichment analysis (top 20 terms) of the 247 DEPs; D: Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis (top 20 pathways) of the 247 DEPs; E: Clustered heatmap of the expression profiles of the 26 core DEPs. MCD: Methionine-choline-deficient; MCS: Methionine-choline-sufficient; JQF: Jiangtang Qingre formula; JQFH: Jiangtang Qingre formula-high; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes.