Integrating proteomics, metabolomics, and molecular docking to elucidate the mechanism of Jiangtang Qingre formula against metabolic dysfunction-associated steatohepatitis

Figure 1 Jiangtang Qingre formula ameliorates hepatic function and lipid profiles in methionine-choline-deficient diet-induced metabolic dysfunction-associated steatohepatitis mice (n = 8). A: Study design and experimental timeline; B: Body weight; C: Representative gross appearance of livers; D: Liver weight and liver-to-body weight ratio; E: Serum alanine aminotransferase and aspartate aminotransferase; F: Serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein, and low-density lipoprotein; G: Hepatic TC and TG. ^aP < 0.05 vs methionine-choline-sufficient (MCS) group; ^bP < 0.01 vs MCS group; ^cP < 0.001 vs MCS group; ^dP < 0.05 vs methionine-choline-deficient (MCD) group; ^eP < 0.01 vs MCD group; ^fP < 0.001 vs MCD group. MCD: Methionine-choline-deficient; MCS: Methionine-choline-sufficient; PPC: Phosphatidylcholine capsules; JQF: Jiangtang Qingre formula; JQFH: Jiangtang Qingre formula-high; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TC: Total cholesterol; TG: Triglycerides; HDL: High-density lipoprotein; LDL: Low-density lipoprotein.