Establishment of a Sprague-Dawley rat model of hepatolithiasis based on common bile duct catheterization

doi:10.3748/wjg.122778

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Dec 28, 2026; 32(48): 122778
Published online Dec 28, 2026. doi: 10.3748/wjg.122778

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Figure 1 Experimental protocol flowchart. SD male rats were randomized to the control group (n = 6, 1 rat/cage) or the LPS test group (n = 6, 1 rat/cage). Surgery was performed on day 0. LPS or equal-volume saline was injected intraductally on days 4, 9, 14, and 19. All animals were sampled on day 24. Bile was collected for FT-IR analysis and bile smear examination; liver and bile duct tissues were collected for HE-stained paraffin sections. FT-IR: Fourier transform infrared spectroscopy; HE: Hematoxylin and eosin; LPS: Lipopolysaccharide; SD: Sprague-Dawley.

Citation: Shi JL, Muhammad T, He TT, Lin ZY, Zhang TG, Liu SY, Yang XL, Yang Y, Hu L, Ran P, Numan M, Li J. Establishment of a Sprague-Dawley rat model of hepatolithiasis based on common bile duct catheterization. World J Gastroenterol 2026; 32(48): 122778
URL: https://www.wjgnet.com/1007-9327/full/v32/i48/122778.htm
DOI: https://dx.doi.org/10.3748/wjg.122778

Shi JL, Muhammad T, He TT, Lin ZY, Zhang TG, Liu SY, Yang XL, Yang Y, Hu L, Ran P, Numan M, Li J. Establishment of a Sprague-Dawley rat model of hepatolithiasis based on common bile duct catheterization. World J Gastroenterol 2026; 32(48): 122778 [DOI: 10.3748/wjg.122778]

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