CLIF-AKI score predicts KDIGO stage 3 acute kidney injury in intensive care unit patients with acute-on-chronic liver failure

Table 5 Continuous net reclassification improvement and integrated discrimination improvement of the chronic liver failure organ failure-acute kidney injury model compared with PIRO, Child-Turcotte-Pugh, chronic liver failure consortium acute-on-chronic liver failure, model for end-stage liver disease, and model for end-stage liver disease-sodium scores for predicting stage 3 acute kidney injury in the external validation cohort

Comparator model	NRI (95%CI)	P value	IDI (95%CI)	P value
PIRO	0.408 (0.126-0.696)	0.008	0.093 (0.037-0.149)	0.004
CTP	1.162 (0.916-1.391)	< 0.001	0.271 (0.209-0.334)	< 0.001
CLIF-C-ACLF	1.000 (0.758-1.242)	< 0.001	0.212 (0.151-0.275)	< 0.001
MELD	1.117 (0.858-1.353)	< 0.001	0.307 (0.237-0.377)	< 0.001
MELD-Na	1.061 (0.802-1.305)	< 0.001	0.294 (0.224-0.362)	< 0.001

CI: Confidence interval; IDI: Integrated discrimination improvement; NRI: Net reclassification improvement; CTP: Child-Turcotte-Pugh; CLIF-C-ACLF: Chronic liver failure consortium acute-on-chronic liver failure; MELD: Model for end-stage liver disease; MELD-Na: Model for end-stage liver disease-sodium.