Integrating metabolomics, clinical factors, and genetic risk for colorectal cancer risk prediction: Model development and internal-external cross-validation

Figure 4 Decision-curve analysis of the four colorectal cancer prediction models at 5 years, 10 years, and 15 years. The models were compared with the treat-all and treat-none strategies. QCancer denotes the adapted QCancer model used in this study. A: Decision-curve analysis (DCA) at 5 years; B: DCA at 10 years; C: DCA at 15 years. DCA: Decision-curve analysis; MetRS: Metabolomic risk score; PRS: Polygenic risk score.