Integrating metabolomics, clinical factors, and genetic risk for colorectal cancer risk prediction: Model development and internal-external cross-validation

Figure 1 Associations between plasma metabolites and incident colorectal cancer risk. Bars represent hazard ratios (HRs) per 1-standard deviation increment in each transformed and standardized metabolic marker. Orange bars indicate statistically significant positive associations with colorectal cancer risk (HR > 1), blue bars indicate statistically significant inverse associations with colorectal cancer risk (HR < 1), and gray bars indicate associations that were not statistically significant after false discovery rate correction. Background sectors indicate metabolic classes.