Ya-Han-Lu-Duan decoction reshapes tumor microenvironment to treat colitis-associated colorectal cancer by regulating arachidonic acid metabolism

doi:10.3748/wjg.122777

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Dec 21, 2026; 32(47): 122777
Published online Dec 21, 2026. doi: 10.3748/wjg.122777

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Figure 8 Ya-Han-Lu-Duan regulates arachidonic acid metabolism by downregulating expression of PTGS2 and ALOX12, synergistically reducing myeloid-derived suppressor cells infiltration and cancer-associated fibroblast activation, improving the tumor microenvironment, and alleviating colitis-associated colorectal cancer. PGE2: Prostaglandin E2; PGG2: Prostaglandin G2; AA: Arachidonic acid; MDSC: Myeloid-derived suppressor cell; TNF: Tumor necrosis factor; IL: Interleukin; CAF: Cancer-associated fibroblast.

Citation: Chen LF, Chen YY, Min FT, Wen WB, Luo SF, Luo Y, Li QR, Xu ZQ, Liu SS, Chen X, Wang N, Cui HT, Wang XR. Ya-Han-Lu-Duan decoction reshapes tumor microenvironment to treat colitis-associated colorectal cancer by regulating arachidonic acid metabolism. World J Gastroenterol 2026; 32(47): 122777
URL: https://www.wjgnet.com/1007-9327/full/v32/i47/122777.htm
DOI: https://dx.doi.org/10.3748/wjg.122777

Chen LF, Chen YY, Min FT, Wen WB, Luo SF, Luo Y, Li QR, Xu ZQ, Liu SS, Chen X, Wang N, Cui HT, Wang XR. Ya-Han-Lu-Duan decoction reshapes tumor microenvironment to treat colitis-associated colorectal cancer by regulating arachidonic acid metabolism. World J Gastroenterol 2026; 32(47): 122777 [DOI: 10.3748/wjg.122777]

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