Ya-Han-Lu-Duan decoction reshapes tumor microenvironment to treat colitis-associated colorectal cancer by regulating arachidonic acid metabolism

doi:10.3748/wjg.122777

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Dec 21, 2026; 32(47): 122777
Published online Dec 21, 2026. doi: 10.3748/wjg.122777

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Figure 7 Ya-Han-Lu-Duan regulates PTGS2 and ALOX12 in arachidonic acid metabolism. A: Western blot detection of PTGS2 and ALOX12 expression levels in colon tissue; B: Molecular docking results of the main components of Ya-Han-Lu-Duan (including Pentahydroxybufostane, Clematoside B, Psammosilenin A and Dulcoside A) with PTGS2 and ALOX12. n = 3 for A. CAC: Colitis-associated colorectal cancer; CON: Control; YHLD-H: High-dose Ya-Han-Lu-Duan.

Citation: Chen LF, Chen YY, Min FT, Wen WB, Luo SF, Luo Y, Li QR, Xu ZQ, Liu SS, Chen X, Wang N, Cui HT, Wang XR. Ya-Han-Lu-Duan decoction reshapes tumor microenvironment to treat colitis-associated colorectal cancer by regulating arachidonic acid metabolism. World J Gastroenterol 2026; 32(47): 122777
URL: https://www.wjgnet.com/1007-9327/full/v32/i47/122777.htm
DOI: https://dx.doi.org/10.3748/wjg.122777

Chen LF, Chen YY, Min FT, Wen WB, Luo SF, Luo Y, Li QR, Xu ZQ, Liu SS, Chen X, Wang N, Cui HT, Wang XR. Ya-Han-Lu-Duan decoction reshapes tumor microenvironment to treat colitis-associated colorectal cancer by regulating arachidonic acid metabolism. World J Gastroenterol 2026; 32(47): 122777 [DOI: 10.3748/wjg.122777]

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