Zfp36 zinc finger CCCH-type inhibits gastric cancer progression by upregulating lipase G and binding its 3’ untranslated region

Figure 5 Integrative analysis of ZFP36-bound RNAs and differentially expressed genes. A: Venn diagram illustrating overlap between ZFP36 peak-associated genes and differentially expressed genes; B: Lipase G (LIPG) expression patterns and statistical differences derived from RNA sequencing and reverse transcription-quantitative polymerase chain reaction validation are shown via bar plot; C: ZFP36 binding peaks within the LIPG gene. Left panel: Read density distribution of ZFP36-binding peaks across LIPG. Right panel: RNA immunoprecipitation-quantitative polymerase chain reaction quantification of LIPG expression based on improved RNA immunoprecipitation sequencing data. ^cP < 0.001, ^dP < 0.0001. DEG: Differentially expressed gene; LIPG: Lipase G; FPKM: Fragments per kilobase of transcript per million mapped reads; NC: Negative control; OE: Overexpression; qPCR: Quantitative polymerase chain reaction.