Real-world predictive model for immune checkpoint inhibitor-induced hepatitis using baseline cytotoxic T-lymphocyte counts

doi:10.3748/wjg.121501

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 21, 2026; 32(47): 121501
Published online Dec 21, 2026. doi: 10.3748/wjg.121501

Table 3 Logistic regression analysis of the risk factors for immune-mediated hepatitis in the training cohort, n (%)

Variables	OR (univariable)		OR (multivariable)
Variables	P value	OR (95%CI)	P value	OR (95%CI)
Gender	< 0.001	0.44 (0.27-0.71)
Age (years)	0.223	0.99 (0.97-1.01)
Primary cancer type	0.128	1.08 (0.98-1.18)
ICI agent type	0.009	0.32 (0.14-0.76)
ICI treatment regimen	0.649	0.68 (0.13-3.55)
WBC (10⁹/L)	0.361	0.98 (0.93-1.03)
HB (g/L)	0.906	1.00 (0.99-1.01)
PLT (10⁹/L)	0.502	1.00 (1.00-1.00)
N (10⁹/L)	0.433	1.00 (0.99-1.02)
LYM (10⁹/L)	0.941	1.00 (0.91-1.11)
MONO (10⁹/L)	0.489	1.09 (0.86-1.38)
ALB (g/L)	0.462	0.99 (0.97-1.01)
GLB (g/L)	0.789	0.99 (0.96-1.03)
TBIL (μmol/L)	0.577	1.22 (0.60-2.49)
DBIL (μmol/L)	0.375	0.99 (0.98-1.01)
TBA (μmol/L)	0.482	0.99 (0.97-1.02)
ALT (U/L)	0.046	1.01 (1.01-1.02)	0.028	1.04 (1.01-1.06)
AST (U/L)	0.634	1.00 (1.00-1.01)
AKP (U/L)	0.742	1.00 (0.99-1.00)
GGT (U/L)	0.460	1.00 (1.00-1.00)
CRP (mg/dL)	0.361	0.98 (0.93-1.03)
C4 (mg/L)	0.014	0.99 (0.99-0.99)	0.038	0.99 (0.97-1.00)
C3 (mg/L)	0.255	1.00 (1.00-1.00)
IgG (g/L)	0.546	0.99 (0.98-1.01)
IgA (mg/L)	0.230	1.00 (1.00-1.00)
IgM (mg/L)	0.695	1.00 (1.00-1.00)
CD3+ CD4+ T cells (cells/μL)	< 0.001	1.01 (1.01-1.01)
CD3+ CD8+ T cells (cells/μL)	< 0.001	1.01 (1.01-1.01)	0.002	1.01 (1.01-1.02)
Th/Ts (CD3+ CD4+/CD3+ CD8+)	0.005	0.57 (0.38-0.84)

OR: Odds ratio; CI: Confidence interval; ICI: Immune checkpoint inhibitor; WBC: White blood cells; HB: Hemoglobin; PLT: Platelet; N: Neutrophil; LYM: Lymphocyte; MONO: Monocyte; ALB: Albumin; GLB: Globulin; TBIL: Total bilirubin; DBIL: Direct bilirubin; TBA: Total bile acid; ALT: Alanine transaminase; AST: Aspartate transaminase; AKP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; CRP: C-reactive protein; C4: Complement 4; C3: Complement 3; IgG: Immunoglobulin G; IgA: Immunoglobulin A; IgM: Immunoglobulin M; Th/Ts: T helper cell/T suppressor cell (cluster of differentiation 3+ cluster of differentiation 4+/cluster of differentiation 3+ cluster of differentiation 8+); CD: Cluster of differentiation.

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Citation: Peng WT, Yang FL, Peng SF, Fu L. Real-world predictive model for immune checkpoint inhibitor-induced hepatitis using baseline cytotoxic T-lymphocyte counts. World J Gastroenterol 2026; 32(47): 121501
URL: https://www.wjgnet.com/1007-9327/full/v32/i47/121501.htm
DOI: https://dx.doi.org/10.3748/wjg.121501

Peng WT, Yang FL, Peng SF, Fu L. Real-world predictive model for immune checkpoint inhibitor-induced hepatitis using baseline cytotoxic T-lymphocyte counts. World J Gastroenterol 2026; 32(47): 121501 [DOI: 10.3748/wjg.121501]

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