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Copyright: ©Author(s) 2026.
World J Gastroenterol. Dec 21, 2026; 32(47): 120094
Published online Dec 21, 2026. doi: 10.3748/wjg.v32.i47.120094
Table 2 Diagnostic modalities in lower gastrointestinal bleeding
Diagnostic modality
Advantages
Disadvantages
Cost-effectiveness
Colonoscopy[2]Diagnostic and therapeutic toolRequires bowel preparation
Limited in massive active bleeding
High cost-effectiveness due to therapeutic capability
Flexible sigmoidoscopy[3]Rapid bedside evaluation; minimal preparationLimited to distal colonOnly in selected cases with suspected distal anorectal pathology
CTA[3]More widely available and better accuracy in identifying the bleeding site with almost 100% accuracy; high sensitivity (79%-95%) and specificity (95%-100%)Requires contrast; risk of nephropathy; contrast dye allergic reaction; non-therapeuticHigh as initial imaging before angiography or surgery
Catheter angiography[2,3]Diagnostic[18] and therapeutic; identifies the bleeding source in 25%-70% of the casesInvasive; risk of bowel ischemia (30%)Moderate
Technetium-99m-tagged red blood[1] cell scintigraphy[2,3]Reveals intermittent bleeding
Non-invasive
Low spatial resolution; may not precisely locate accurate bleeding siteModerate
Video capsule endoscopy[2]Non-invasive diagnostic alternative that allows the entire small bowel to be explored in 79%-90%Only diagnostic; risk of capsule retention in 2% of patients undergoing study for small bowel bleedingLow
Barium small bowel study[2]Identifies structural abnormalitiesLow sensitivity in active bleedingLow


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