Trans-3-indoleacrylic acid ameliorates dextran sulfate sodium-induced colitis by modulating macrophage M1 polarization through the aryl hydrocarbon receptor pathway

Figure 1 Trans-3-indoleacrylic acid ameliorates acute dextran sulfate sodium-induced colitis in mice. A: Schematic of the animal experiment; B: Body weight change (%) of mice during dextran sulfate sodium (DSS) treatment; C: Disease activity index score during DSS treatment; D: Representative images of colons from each group; E: Colon length; F: Spleen index; G: Representative images of colonic sections stained with hematoxylin and eosin; H: Histological scores. The data are shown as the mean ± SD (n = 6 mice per group). Group comparisons were analyzed using one-way ANOVA with Sidak’s multiple comparisons test. In B and C, the P values indicate the differences between groups on day 7. ^aP < 0.001, ^bP < 0.0001. DSS: Dextran sulfate sodium; IDA: Trans-3-indoleacrylic acid; DAI: Disease activity index; H&E: Hematoxylin and eosin.