Clinical features and biomarkers associated with ulcerative colitis: A systematic review and meta-analysis

doi:10.3748/wjg.123374

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World Journal of Gastroenterology

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1007-9327

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Meta-Analysis

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Dec 14, 2026; 32(46): 123374
Published online Dec 14, 2026. doi: 10.3748/wjg.123374

Table 6 Meta-analysis of inflammatory markers in active ulcerative colitis compared with clinical remission and healthy controls

	Number of studies	MD (95%CI)	I² value
FC levels
Active UC vs CR	24	387.04 (292.55-481.54)	99.90%
Active UC vs HCs	11	486.94 (371.31-602.58)	99.70%
ESR levels
Active UC vs CR	42	14.33 (11.93-16.73)	98.70%
Active UC vs HCs	24	17.40 (13.42-21.38)	99.50%
CRP levels
Active UC vs CR	67	12.94 (10.48-15.41)	99.40%
Active UC vs HCs	38	16.81 (12.67-20.95)	99.90%

MD: Mean difference; CI: Confidence interval; UC: Ulcerative colitis; FC: Fecal calprotectin; CR: Clinical remission; HCs: Healthy controls; ESR: Erythrocyte sedimentation rate; CRP: C-reactive protein.

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Citation: Liu K, Zhang XH, Zhou XY, Liu YX, Pan SQ, Liu TX, Russell R, Wang XH, Yao YP, Zhao XJ, Sun HY, Ju CL, Liu JP, Liu ZL. Clinical features and biomarkers associated with ulcerative colitis: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(46): 123374
URL: https://www.wjgnet.com/1007-9327/full/v32/i46/123374.htm
DOI: https://dx.doi.org/10.3748/wjg.123374

Liu K, Zhang XH, Zhou XY, Liu YX, Pan SQ, Liu TX, Russell R, Wang XH, Yao YP, Zhao XJ, Sun HY, Ju CL, Liu JP, Liu ZL. Clinical features and biomarkers associated with ulcerative colitis: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(46): 123374 [DOI: 10.3748/wjg.123374]

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