Clinical features and biomarkers associated with ulcerative colitis: A systematic review and meta-analysis

doi:10.3748/wjg.123374

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

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World J Gastroenterol. Dec 14, 2026; 32(46): 123374
Published online Dec 14, 2026. doi: 10.3748/wjg.123374

Table 4 Meta-analysis of systemic signs in ulcerative colitis vs controls

	Number of studies	OR (95%CI)	I² value
Anemia
UC compared to CD	45	0.5845 (0.4900-0.6973)	69.80%
UC compared to ITB	1	0.24 (0.0683-0.8433)	Ne
UC compared to IBD-U	4	1.3163 (0.8129-2.1316)	35.30%
UC compared to other	2	0.6 (0.2548-1.4129)	0.00%
Fatigue
UC compared to CD	12	0.8994 (0.5129-1.5773)	78.80%
UC compared to IC	1	0.5496 (0.0255-11.8444)	Ne
UC compared to ITB	2	0.34 (0.1144-1.0105)	0.00%
UC compared to IBD-U	2	0.5497 (0.2986-1.0119)	0.00%
UC compared to other	2	0.7448 (0.4435-1.2509)	0.00%
Fever
UC compared to CD	67	0.6065 (0.5041-0.7297)	63.90%
UC compared to IC	11	0.7294 (0.4197-1.2676)	22.70%
UC compared to ITB	7	0.2282 (0.0852-0.6110)	73.00%
UC compared to IE	1	83.8148 (4.6836-1499.8891)	Ne
UC compared to IBD-U	6	1.0947 (0.6892-1.7388)	0.00%
UC compared to other	5	0.9187 (0.2980-2.8329)	57.40%
Weight loss
UC compared to CD	57	0.4922 (0.4076-0.5943)	71.40%
UC compared to IC	1	8 (3.0025-21.3153)	Ne
UC compared to ITB	3	0.3211 (0.0706-1.4613)	69.40%
UC compared to IBD-U	5	1.4825 (0.8605-2.5540)	0.00%
UC compared to Other	4	1.0331 (0.4837-2.2067)	0.00%

UC: Ulcerative colitis; CD: Crohn’s disease; IC: Ischemic colitis; ITB: Intestinal tuberculosis; OR: Odds ratios; CI: Confidence intervals; IE: Infectious enteritis; IBD-U: Inflammatory bowel disease unclassified; Other: Unspecified diseases; Ne: There is only one type of disease in the control group, or only a single study was included, precluding the assessment of heterogeneity.

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Citation: Liu K, Zhang XH, Zhou XY, Liu YX, Pan SQ, Liu TX, Russell R, Wang XH, Yao YP, Zhao XJ, Sun HY, Ju CL, Liu JP, Liu ZL. Clinical features and biomarkers associated with ulcerative colitis: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(46): 123374
URL: https://www.wjgnet.com/1007-9327/full/v32/i46/123374.htm
DOI: https://dx.doi.org/10.3748/wjg.123374

Liu K, Zhang XH, Zhou XY, Liu YX, Pan SQ, Liu TX, Russell R, Wang XH, Yao YP, Zhao XJ, Sun HY, Ju CL, Liu JP, Liu ZL. Clinical features and biomarkers associated with ulcerative colitis: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(46): 123374 [DOI: 10.3748/wjg.123374]

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