Development and validation of a clinical data-based diagnostic model for neonatal intrahepatic cholestasis caused by citrin deficiency

doi:10.3748/wjg.121360

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 14, 2026; 32(46): 121360
Published online Dec 14, 2026. doi: 10.3748/wjg.121360

Table 2 Logistic regression analyses of predictors of neonatal intrahepatic cholestasis caused by citrin deficiency

Characteristic	Univariate analysis		Multivariate analysis
Characteristic	OR (95%CI)	P value	OR (95%CI)	P value
Age	1.73 (1.34-2.23)	0.000	9.74 (3.56-26.69)	0.000
WBC	1.22 (1.15-1.31)	0.000	2.23 (0.56-8.95)	0.258
N	1.96 (1.64-2.35)	0.000	0.42 (0.08-2.16)	0.299
L	1.12 (1.04-1.22)	0.004	0.49 (0.11-2.19)	0.347
HB	0.99 (0.97-1.00)	0.026	1.01 (0.97-1.05)	0.727
PLT	1.00 (1.00-1.01)	0.000	1.00 (1.00-1.01)	0.352
CRP	1.31 (1.15-1.50)	0.000	1.09 (0.77-1.53)	0.631
TBIL	1.01 (1.00-1.01)	0.002	0.92 (0.61-1.39)	0.696
DBIL	0.99 (0.99-1.00)	0.014	1.06 (0.70-1.61)	0.782
IBIL	1.03 (1.02-1.04)	0.000	1.11 (0.73-1.69)	0.615
ALB	0.65 (0.59-0.70)	0.000	0.75 (0.61-0.92)	0.005
GLO	0.90 (0.85-0.96)	0.001	0.99 (0.90-1.10)	0.894
ALT	0.99 (0.98-0.99)	0.000	1.00 (0.99-1.01)	0.494
AST	1.00 (0.99-1.00)	0.000	1.00 (1.00-1.01)	0.641
AST/ALT	4.15 (2.96-5.80)	0.000	1.85 (0.76-4.47)	0.173
TBAC	1.01 (1.01-1.02)	0.000	0.99 (0.98-1.00)	0.097
LCAT	1.47 (1.27-1.70)	0.000	1.57 (1.04-2.37)	0.031
NH₄	1.02 (1.02-1.03)	0.000	1.02 (01.00-1.04)	0.07
PT	2.22 (1.86-2.65)	0.000	1.08 (0.94-1.23)	0.291
APTT	1.13 (1.08-1.17)	0.000	0.98 (0.87-1.11)	0.773
INR	33437.21 (3651.70-306172.16)	0.000	167.61 (3.28-8557.58)	0.011
FIB	0.97 (0.96-0.97)	0.000	0.98 (0.97-0.99)	0.001

ALB: Albumin; ALT: Alanine aminotransferase; APTT: Activated partial thromboplastin time; AST: Aspartate aminotransferase; CI: Confidence interval; CRP: C-reactive protein; DBIL: Direct bilirubin; FIB: Fibrinogen; GGT: Gamma-glutamyl transferase; GLO: Globulin; GLU: Glucose; HB: Hemoglobin; IBIL: Indirect bilirubin; INR: International normalized ratio; L: Lymphocytes; LACT: Lactate; N: Neutrophils; NH₄: Blood ammonia; OR: Odds ratio; PLT: Platelet; PT: Prothrombin time; TBAC: Total bile acids; TBIL: Total bilirubin; TCHO: Total cholesterol; TG: Triglycerides; WBC: White blood cell.

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Citation: Jiang T, Qin XM, Liu YW, Li SJ, Liu N, Ouyang WX, Peng SX. Development and validation of a clinical data-based diagnostic model for neonatal intrahepatic cholestasis caused by citrin deficiency. World J Gastroenterol 2026; 32(46): 121360
URL: https://www.wjgnet.com/1007-9327/full/v32/i46/121360.htm
DOI: https://dx.doi.org/10.3748/wjg.121360

Jiang T, Qin XM, Liu YW, Li SJ, Liu N, Ouyang WX, Peng SX. Development and validation of a clinical data-based diagnostic model for neonatal intrahepatic cholestasis caused by citrin deficiency. World J Gastroenterol 2026; 32(46): 121360 [DOI: 10.3748/wjg.121360]

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