Development and validation of a clinical data-based diagnostic model for neonatal intrahepatic cholestasis caused by citrin deficiency

Table 1 Comparison of baseline clinical features and demographic characteristics between the neonatal intrahepatic cholestasis caused by citrin deficiency group and the control group

Parameter	Reference interval	NICCD group, n = 170	Control group, n = 196	T	P value
Age in months		2.47 ± 1.26	1.98 ± 0.70	4.69	0.000
WBC (× 109)	4.3-14.2	13.10 ± 4.14	10.54 ± 3.14	6.72	0.000
N (× 109)	0.6-7.5	4.10 ± 1.96	2.54 ± 1.31	9.02	0.000
L (× 109)	2.4-9.5	7.57 ± 2.99	6.73 ± 2.41	3.00	0.003
HB (g/L)	97-183	100.20 ± 16.91	104.4 ± 17.95	-2.27	0.024
PLT (× 109)	183-614 × 109	501.40 ± 173.50	420.50 ± 135.97	5.00	0.000
CRP (mg/L)	0-5	2.29 ± 2.65	1.31 ± 1.77	4.21	0.000
TBIL (mol/L)	3-20	163.90 ± 65.47	137.20 ± 87.32	3.28	0.001
DBIL (mol/L)	1.7-6.8	78.82 ± 39.05	91.66 ± 55.48	-2.52	0.012
IBIL (mol/L)	1.3-18.3	85.16 ± 45.79	41.62 ± 31.77	10.67	0.000
ALB (g/L)	35-50	30.71 ± 4.67	38.02 ± 3.27	-17.51	0.000
GLO (g/L)	9-27	16.37 ± 4.03	18.62 ± 9.03	-2.988	0.003
ALT (U/L)	8-71	63.18 ± 97.61	187.00 ± 207.65	-7.12	0.000
AST (U/L)	21-80	129.20 ± 115.20	203.20 ± 182.28	-4.56	0.000
ALT/AST		2.60 ± 1.34	1.36 ± 0.77	10.97	0.000
TBAC (mol/L)	0.5-10	180.80 ± 67.36	125.40 ± 59.75	8.35	0.000
GGT (U/L)	9-150	186.10 ± 73.35	198.40 ± 33.66	-0.47	0.642
GLU (mmol/L)	3.89-6.4	4.87 ± 8.94	4.66 ± 1.12	0.33	0.745
TG (mmol/L)	0.33-1.82	1.65 ± 0.76	1.63 ± 0.72	0.27	0.789
TCHO (mmol/L)	0-5.2	4.36 ± 1.32	4.12 ± 2.75	1.06	0.292
LACT (mmol/L)	0.5-2.44	4.58 ± 1.65	3.69 ± 1.44	5.51	0.000
NH4 (mol/L)	10-47	76.53 ± 44.69	51.54 ± 26.04	6.63	0.000
PT (seconds)	10-14	17.29 ± 8.43	13.27 ± 2.87	6.27	0.000
APTT	28-48	49.42 ± 12.26	43.54 ± 5.04	6.14	0.000
INR	0.8-1.5	1.45 ± 1.21	1.00 ± 0.11	5.27	0.000
FIB (mg/dL)	170-450	135.00 ± 54.16	288.80 ± 70.80	-23.06	0.000

NICCD: Neonatal intrahepatic cholestasis caused by citrin deficiency; ALB: Albumin; ALT: Alanine aminotransferase; APTT: Activated partial thromboplastin time; AST: Aspartate aminotransferase; CRP: C-reactive protein; DBIL: Direct bilirubin; FIB: Fibrinogen; GGT: Gamma-glutamyl transferase; GLO: Globulin; GLU: Glucose; HB: Hemoglobin; IBIL: Indirect bilirubin; L: Lymphocytes; INR: International normalized ratio; LACT: Lactate; N: Neutrophils; NH4: Blood ammonia; PLT: Platelets; PT: Prothrombin time; TBAC: Total bile acids; TBIL: Total bilirubin; TCHO: Total cholesterol; TG: Triglycerides; WBC: White blood cell.