Impact of glucagon-like peptide-1 receptor agonists on bowel preparation quality for colonoscopy in type 2 diabetes

doi:10.3748/wjg.121313

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World Journal of Gastroenterology

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1007-9327

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Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Dec 14, 2026; 32(46): 121313
Published online Dec 14, 2026. doi: 10.3748/wjg.121313

Table 3 Multivariable analysis of risk factors for inadequate bowel preparation

	Propensity matched patients (n = 341)
	Unadjusted OR (95%CI)	P value	Adjusted OR (95%CI)	P value
GLP-1RA	1.85 (1.05-3.27)	0.034	1.89 (1.05-3.39)	0.034
Age	1.02 (0.99-1.06)	0.239	1.03 (0.99-1.06)	0.149
Sex (male)	2.44 (1.23-4.82)	0.011	2.46 (1.24-4.89)	0.010
BMI	1.39 (0.19-10.16)	0.746	0.93 (0.11-7.91)	0.948
HbA1c	0.31 (0.02-3.90)	0.362	0.21 (0.01-3.27)	0.265
Insulin use	1.39 (0.77-2.52)	0.277	1.45 (0.81-2.59)	0.210
DM complication	0.72 (0.40-1.29)	0.264
DM duration	1.02 (0.93-1.12)	0.625
Hypertension	1.25 (0.68-2.30)	0.479
Chronic kidney disease	0.77 (0.30-1.95)	0.577
Cardiovascular disease	1.55 (0.75-3.22)	0.241
Cerebrovascular accident	1.32 (0.68-2.57)	0.412
GI modulator
Increasing motility¹	1.55 (0.60-3.98)	0.363
Decreasing motility²	0.69 (0.08-6.07)	0.738

¹Gastrointestinal modulators increasing motility included prokinetic agents and laxative agents.

²Gastrointestinal modulators decreasing motility included tricyclic antidepressants, opioid medications, anticholinergic agents and antidiarrheal agents.

GLP-1RA: Glucagon-like peptide-1 receptor agonist; BMI: Body mass index; HbA1c: Hemoglobin A1c; DM: Diabetes mellitus; GI: Gastrointestinal; CI: Confidence interval; OR: Odds ratio.

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Citation: Park HJ, Oh YE, Chi SA, Kim M, Kim JE, Hong SN, Min BH, Kim YH, Chang DK, Kim TS, Kim ER. Impact of glucagon-like peptide-1 receptor agonists on bowel preparation quality for colonoscopy in type 2 diabetes. World J Gastroenterol 2026; 32(46): 121313
URL: https://www.wjgnet.com/1007-9327/full/v32/i46/121313.htm
DOI: https://dx.doi.org/10.3748/wjg.121313

Park HJ, Oh YE, Chi SA, Kim M, Kim JE, Hong SN, Min BH, Kim YH, Chang DK, Kim TS, Kim ER. Impact of glucagon-like peptide-1 receptor agonists on bowel preparation quality for colonoscopy in type 2 diabetes. World J Gastroenterol 2026; 32(46): 121313 [DOI: 10.3748/wjg.121313]

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