Multi-omics analysis identifies COX6A2/SCF/c-Kit-mediated mitochondrial remodeling as a key mechanism of Tangwei’an decoction in diabetic gastroparesis

Figure 8 COX6A2 links Tangwei’an to SCF/c-Kit signaling and mitochondrial dynamics in mouse gastric smooth muscle cells. A: Representative immunofluorescence images of COX6A2 in the indicated groups; B-G: Representative western blots and densitometric quantification of COX6A2, SCF, c-Kit, DRP1 and MFN2 in mouse gastric smooth muscle cells (n = 3); H: ATP content in mouse gastric smooth muscle cells (n = 6). ^eP < 0.01 vs the “high glucose(-) Tangwei’an(-)” group, ^fP < 0.05 vs the “high glucose(+) Tangwei’an(-)” group, ^gP < 0.01 vs the “high glucose(+) Tangwei’an(-)” group. HG: High glucose; TWA: Tangwei’an.