Multi-omics analysis identifies COX6A2/SCF/c-Kit-mediated mitochondrial remodeling as a key mechanism of Tangwei’an decoction in diabetic gastroparesis

Figure 7 Tangwei’an rescues mitochondrial dysfunction in high glucose-injured mouse gastric smooth muscle cells. A: ATP content in mouse gastric smooth muscle cells (n = 6); B: Reactive oxygen species; C: Reactive oxygen species levels quantified as MFI (a.u.); D: Representative JC-1 images and quantification of mitochondrial membrane potential as the red/green ratio (a.u.); E: Representative western blots and densitometric quantification of DRP1 and MFN2 in mouse gastric smooth muscle cells (n = 3). Data are presented as the mean ± SEM. ^bP < 0.01 vs Control group, ^dP < 0.01 vs the Model group. TWA: Tangwei’an; ROS: Reactive oxygen species.