Multi-omics analysis identifies COX6A2/SCF/c-Kit-mediated mitochondrial remodeling as a key mechanism of Tangwei’an decoction in diabetic gastroparesis

doi:10.3748/wjg.122523

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Dec 7, 2026; 32(45): 122523
Published online Dec 7, 2026. doi: 10.3748/wjg.122523

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Figure 4 Metabonomics analysis of Tangwei’an treated diabetic gastroparesis mice. A: Principal component analysis of metabolites; B: PLS-DA analysis of metabolites; C: OPLS-DA analysis model of intergroup differential metabolites; D: Volcano plot of differentially expressed metabolites in metabonomics; E: Heatmap visualization of metabolites in Control, Model, and Tangwei’an groups; F: Venn and UpSet diagram analysis of differentially expressed metabolites; G: Lollipop plot of metabolites in Tangwei’an decoction-treated diabetic gastroparesis; H: Kyoto Encyclopedia of Genes and Genomes analysis of differentially expressed metabolites in Tangwei’an decoction-treated diabetic gastroparesis. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. TWA: Tangwei’an; VIP: Vasoactive intestinal peptide.

Citation: Zhang YX, Fang XY, Zhang YJ, Yin RY, Li B, Tian JX. Multi-omics analysis identifies COX6A2/SCF/c-Kit-mediated mitochondrial remodeling as a key mechanism of Tangwei’an decoction in diabetic gastroparesis. World J Gastroenterol 2026; 32(45): 122523
URL: https://www.wjgnet.com/1007-9327/full/v32/i45/122523.htm
DOI: https://dx.doi.org/10.3748/wjg.122523

Zhang YX, Fang XY, Zhang YJ, Yin RY, Li B, Tian JX. Multi-omics analysis identifies COX6A2/SCF/c-Kit-mediated mitochondrial remodeling as a key mechanism of Tangwei’an decoction in diabetic gastroparesis. World J Gastroenterol 2026; 32(45): 122523 [DOI: 10.3748/wjg.122523]

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