Multi-omics analysis identifies COX6A2/SCF/c-Kit-mediated mitochondrial remodeling as a key mechanism of Tangwei’an decoction in diabetic gastroparesis

Figure 3 Proteomics analysis of Tangwei’an treated diabetic gastroparesis mice. A: Principal component analysis score plot of Model and Control groups; B: Principal component analysis score plot of Tangwei’an (TWA) and Model groups; C: Venn diagram of differentially expressed proteins (DEPs); D: Volcano plots illustrating DEPs of Model vs Control; E: Volcano plots illustrating DEPs of TWA vs Control; F: The UpSet intersection diagram presented the common protein distribution of four types; G: Gene Ontology enrichment analysis of differentially expressed proteins between the TWA and Model groups, including biological process, cellular component, and molecular function; H: Gene Ontology analysis diagram of diabetic gastroparesis for TWA treatment of diabetic gastroparesis; I: Kyoto Encyclopedia of Genes and Genomes enrichment analysis among TWA and Model; J: Kyoto Encyclopedia of Genes and Genomes enrichment chord diagram. TWA: Tangwei’an; KEGG: Kyoto Encyclopedia of Genes and Genomes; GO: Gene Ontology; PCA: Principal component analysis.