Dendrobium officinale polysaccharides attenuates spasmolytic polypeptide-expressing metaplasia via dual modulation of gastric epithelial cell fate and macrophage polarization

doi:10.3748/wjg.122498

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Dec 7, 2026; 32(45): 122498
Published online Dec 7, 2026. doi: 10.3748/wjg.122498

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Figure 7 Molecular mechanism of Dendrobium officinale polysaccharides in inhibiting spasmolytic polypeptide-expressing metaplasia. DOP: Dendrobium officinale polysaccharides; IL: Interleukin; BMDMs: Bone marrow-derived macrophages; SPEM: Spasmolytic polypeptide-expressing metaplasia; TFF2: Trefoil factor 2; AQP5: Aquaporin 5.

Citation: Zhao Y, Lu XF, Liu L, Fang H, Sun S, Liu HN, Sun YZ. Dendrobium officinale polysaccharides attenuates spasmolytic polypeptide-expressing metaplasia via dual modulation of gastric epithelial cell fate and macrophage polarization. World J Gastroenterol 2026; 32(45): 122498
URL: https://www.wjgnet.com/1007-9327/full/v32/i45/122498.htm
DOI: https://dx.doi.org/10.3748/wjg.122498

Zhao Y, Lu XF, Liu L, Fang H, Sun S, Liu HN, Sun YZ. Dendrobium officinale polysaccharides attenuates spasmolytic polypeptide-expressing metaplasia via dual modulation of gastric epithelial cell fate and macrophage polarization. World J Gastroenterol 2026; 32(45): 122498 [DOI: 10.3748/wjg.122498]

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