Dendrobium officinale polysaccharides attenuates spasmolytic polypeptide-expressing metaplasia via dual modulation of gastric epithelial cell fate and macrophage polarization

Figure 5 Western blot analysis of M2 macrophage polarization and the IL-13/STAT6 signaling pathway. A: Western blot analysis of M2 macrophage polarization markers; B: Relative protein quantification (CD206, ARG1, CD163, iNOS) performed using Image Lab 6.0; C: Western blot analysis of interleukin-13 and STAT6 protein expression; D: Relative protein quantification (interleukin-13, p-STAT6/STAT6) performed using Image Lab 6.0. The data are represented as mean ± SD, n = 3. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, vs control; ^dP < 0.05, ^eP < 0.01, vs spasmolytic polypeptide-expressing metaplasia model. Ctrl: Control; SPEM: Spasmolytic polypeptide-expressing metaplasia; WFC: Weifuchun capsule; H-DOP: High-dose Dendrobium officinale polysaccharides; L-DOP: Low-dose Dendrobium officinale polysaccharides; IL: Interleukin.