Targeting inflammasome in digestive diseases: A dual approach of Western and Chinese medicine

Figure 2 Comparison of intervention targets between Western medicine and traditional Chinese medicine on the NOD-like receptor family pyrin domain-containing 3 inflammasome signaling pathway. Visualize the distinct and overlapping targets of Western medicine inhibitors (e.g., MCC950 targeting NOD-like receptor family pyrin domain-containing 3 ATPase activity) and traditional Chinese medicine components (e.g., saikosaponin-d inhibiting nuclear factor kappa B). NLRP3: NOD-like receptor family pyrin domain-containing 3; TLRs: Toll-like receptors; PAMPs: Pathogen-associated molecular patterns; DAMPs: Damage-associated molecular patterns; NF-κB: Nuclear factor kappa B; IL: Interleukin; ROS: Reactive oxygen species; ASC: Apoptosis-associated speck-like protein containing a CARD; GSDMD: Gasdermin D; TCM: Traditional Chinese medicine.