Pegylated interferon α-2b add-on to nucleos(t)ide analogues reduces hepatocellular carcinoma and decompensation in advanced fibrotic chronic hepatitis B

doi:10.3748/wjg.121641

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Dec 7, 2026; 32(45): 121641
Published online Dec 7, 2026. doi: 10.3748/wjg.121641

Table 5 Comparison of efficacy measures between the nucleos(t)ide analogue monotherapy vs pegylated interferon α-2b and nucleos(t)ide analogue combination therapy: Hepatitis b surface antigen clearance rates, n (%)

Group	Total	HBsAg clearance	Non-HBsAg clearance	χ²	P value
NA	302	2 (0.71)	300 (99.29)	50.842	< 0.001
Peg-IFNα-2b + NA	302	52 (19.19)	250 (81.81)	50.842	< 0.001

HBsAg: Hepatitis B surface antigen; NA: Nucleos(t)ide analogue; Peg-IFNα-2b: Pegylated interferon α-2b.

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Citation: Li XY, Huang JT, Liu T, Li YY, Zhe L, Cao H, Lin BL. Pegylated interferon α-2b add-on to nucleos(t)ide analogues reduces hepatocellular carcinoma and decompensation in advanced fibrotic chronic hepatitis B. World J Gastroenterol 2026; 32(45): 121641
URL: https://www.wjgnet.com/1007-9327/full/v32/i45/121641.htm
DOI: https://dx.doi.org/10.3748/wjg.121641

Li XY, Huang JT, Liu T, Li YY, Zhe L, Cao H, Lin BL. Pegylated interferon α-2b add-on to nucleos(t)ide analogues reduces hepatocellular carcinoma and decompensation in advanced fibrotic chronic hepatitis B. World J Gastroenterol 2026; 32(45): 121641 [DOI: 10.3748/wjg.121641]

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