Efficacy and safety of neuromodulators combined with proton pump inhibitors for non-erosive reflux disease: A randomized clinical trial

Figure 1 The protocol of the study. Gastroesophageal reflux disease questionnaire scores were collected every 2 weeks during the study. Patient Health Questionnaire-9, Generalized Anxiety Disorder 7-item scale, Pittsburgh Sleep Quality Index, Gastroesophageal Reflux Disease Health-Related Quality of Life were collected at baseline, week 2 and week 12. Medication possession ratio was calculated at week 2. Cost-effectiveness analysis was calculated at week 12. CEA: Cost-effectiveness analysis; GAD-7: Generalized Anxiety Disorder 7-item scale; GerdQ: Gastroesophageal Reflux Disease Questionnaire; GERD-HRQL: Gastroesophageal Reflux Disease Health-Related Quality of Life; PHQ-9: Patient Health Questionnaire-9; PSQI: Pittsburgh Sleep Quality Index.