Efficacy and safety of neuromodulators combined with proton pump inhibitors for non-erosive reflux disease: A randomized clinical trial

doi:10.3748/wjg.122876

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World Journal of Gastroenterology

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1007-9327

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Randomized Clinical Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 28, 2026; 32(44): 122876
Published online Nov 28, 2026. doi: 10.3748/wjg.122876

Table 3 Symptom scores at baseline, week 2 and week 12 in the per-protocol population, mean (SD)/median (interquartile range)

Variable	Time	FM + LPZ	P + LPZ	P value
GerdQ	Week 0	12.0 (10.0-14.0)	12.0 (10.0-15.0)
	Week 2	6.0 (6.0-8.0)	8.0 (7.0-10.0)	< 0.001
	Week 12	6.0 (6.0-8.0)	8.5 (8.0-10.0)	< 0.001
GAD-7	Week 0	3.0 (1.0-7.0)	3.0 (2.0-5.0)
	Week 2	2.0 (0.0-3.0)	3.0 (2.0-4.0)	< 0.001
	Week 12	2.0 (0.5-3.0)	3.0 (2.0-3.0)	< 0.001
PHQ-9	Week 0	4.0 (1.0-8.0)	4.5 (2.0-8.0)
	Week 2	2.0 (0.0-3.0)	3.5 (2.0-6.0)	< 0.001
	Week 12	2.0 (0.0-4.0)	3.5 (2.0-6.0)	< 0.001
PSQI	Week 0	7.4 (4.4)	7.8 (4.1)
	Week 2	5.4 (3.0)	7.6 (4.0)	< 0.001
	Week 12	4.7 (2.7)	7.7 (4.3)	< 0.001
GERD-HRQL	Week 0	13.2 (5.0)	13.6 (4.7)
	Week 2	3.8 (3.2)	7.7 (4.7)	< 0.001
	Week 12	2.7 (2.5)	7.3 (3.8)	< 0.001

GAD-7: Generalized Anxiety Disorder 7-item scale; GerdQ: Gastroesophageal reflux disease questionnaire; GERD-HRQL: Gastroesophageal Reflux Disease Health-Related Quality of Life; PHQ-9: Patient Health Questionnaire-9; PSQI: Pittsburgh Sleep Quality Index; FM: Flupentixol-melitracen; LPZ: Lansoprazole; P + LPZ: Lansoprazole plus placebo.

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Citation: Yin KH, Wang XY, Wang XY, Cheng L, Wang B, Wang QQ, Qiao Y, Tang XR, Yan XJ, Chen SL. Efficacy and safety of neuromodulators combined with proton pump inhibitors for non-erosive reflux disease: A randomized clinical trial. World J Gastroenterol 2026; 32(44): 122876
URL: https://www.wjgnet.com/1007-9327/full/v32/i44/122876.htm
DOI: https://dx.doi.org/10.3748/wjg.122876

Yin KH, Wang XY, Wang XY, Cheng L, Wang B, Wang QQ, Qiao Y, Tang XR, Yan XJ, Chen SL. Efficacy and safety of neuromodulators combined with proton pump inhibitors for non-erosive reflux disease: A randomized clinical trial. World J Gastroenterol 2026; 32(44): 122876 [DOI: 10.3748/wjg.122876]

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