Efficacy and safety of neuromodulators combined with proton pump inhibitors for non-erosive reflux disease: A randomized clinical trial

doi:10.3748/wjg.122876

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Clinical Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 28, 2026; 32(44): 122876
Published online Nov 28, 2026. doi: 10.3748/wjg.122876

Table 2 Subgroup analysis of the primary outcome

Subgroup	Number of responsive/total patients		RR (95%CI)	P value for interaction
Subgroup	FM + LPZ group	P + LPZ group	RR (95%CI)	P value for interaction
All patients	71/82	51/82	1.39 (1.15-1.68)
Mood disorders
With anxiety/depression	38/44	27/45	1.44 (1.10-1.88)	0.706
No anxiety/depression	33/38	24/37	1.34 (1.03-1.75)	0.706

RR: Relative risk; FM: Flupentixol-melitracen; LPZ: Lansoprazole; P + LPZ: Lansoprazole plus placebo.

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Citation: Yin KH, Wang XY, Wang XY, Cheng L, Wang B, Wang QQ, Qiao Y, Tang XR, Yan XJ, Chen SL. Efficacy and safety of neuromodulators combined with proton pump inhibitors for non-erosive reflux disease: A randomized clinical trial. World J Gastroenterol 2026; 32(44): 122876
URL: https://www.wjgnet.com/1007-9327/full/v32/i44/122876.htm
DOI: https://dx.doi.org/10.3748/wjg.122876

Yin KH, Wang XY, Wang XY, Cheng L, Wang B, Wang QQ, Qiao Y, Tang XR, Yan XJ, Chen SL. Efficacy and safety of neuromodulators combined with proton pump inhibitors for non-erosive reflux disease: A randomized clinical trial. World J Gastroenterol 2026; 32(44): 122876 [DOI: 10.3748/wjg.122876]

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