Add-on trimebutine-maleate does not improve tolerability or eradication in bismuth quadruple therapy for Helicobacter pylori

doi:10.3748/wjg.122850

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World Journal of Gastroenterology

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1007-9327

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Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 28, 2026; 32(44): 122850
Published online Nov 28, 2026. doi: 10.3748/wjg.122850

Table 3 Medication adherence and eradication outcomes, mean ± SD/n (%)

Outcome	Control (n = 66)	Trimebutine (n = 66)	P value
Mean adherence, %	85.0 ± 33.0	81.6 ± 36.8	0.764
Adherence ≥ 80%	53 (80.3)	52 (78.8)	> 0.999
Completed 14-day regimen	59 (89.4)	59 (89.4)	> 0.999
Lost to follow-up for UBT	9 (13.6)	11 (16.7)	0.809
ITT eradication n/N (%), (95%CI)	50/66 (75.8) (64.2-84.5)	49/66 (74.2) (62.6-83.3)	> 0.999
PP eradication, n/N (%), (95%CI)	50/57 (87.7) (76.8-93.9)	49/55 (89.1) (78.2-94.9)	> 0.999

95% confidence intervals for single proportions calculated by the Wilson method. Continuous variables compared by Mann-Whitney U-test; categorical variables by Fisher’s exact test. CI: Confidence interval; ITT: Intention-to-treat; PP: Per-protocol; UBT: Urea breath test.

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Citation: Gong EJ, Bang CS. Add-on trimebutine-maleate does not improve tolerability or eradication in bismuth quadruple therapy for Helicobacter pylori. World J Gastroenterol 2026; 32(44): 122850
URL: https://www.wjgnet.com/1007-9327/full/v32/i44/122850.htm
DOI: https://dx.doi.org/10.3748/wjg.122850

Gong EJ, Bang CS. Add-on trimebutine-maleate does not improve tolerability or eradication in bismuth quadruple therapy for Helicobacter pylori. World J Gastroenterol 2026; 32(44): 122850 [DOI: 10.3748/wjg.122850]

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