Microbiota-nutrition sequential therapy for refractory radiation proctitis: A case report

Figure 6 Dynamic changes of serum cytokines at baseline and post microbiota-nutrition sequential therapy. A: Profiles of six low-abundance cytokines. Pro-inflammatory interferon-γ and tumor necrosis factor-α markedly declined after treatment, whereas anti-inflammatory interleukin (IL)-4 and IL-10 slightly increased, with mild elevation of IL-2 and IL-1β; B: Variation of high-level pro-inflammatory cytokines IL-6 and IL-8: IL-6 decreased obviously, while IL-8 slightly rose within physiological range. X-axis: Baseline, post two cycles of combined therapy; Y-axis: Cytokine concentration (pg/mL). TNF-α: Tumor necrosis factor-α; IL: Interleukin; IFN-γ: Interferon-γ.