Applications of nanozymes in the diagnosis and treatment of gastrointestinal malignancies

Table 3 Applications of nanozymes in the treatment of gastric malignancies

Type pathway	Nanozyme	Mimic activity	Function	Tumor model	Ref.
DNA-templated Ag@Pd alloy nanoclusters	Ag@Pd	Peroxidase	Exhibit high photothermal conversion efficiency, enhanced reactive oxygen species generation, improved permeability, and enhance nanocatalytic therapy	MKN-45 cells and mouse model	[42]
Drug delivery system based on nanomotors	MnO2-Au-mSiO2	Peroxidase	Effectively link nanomotors, enhance reactive oxygen species production, and activate the stimulator of interferon genes pathway	MFC cells and mouse models; gastric cancer organoid models	[54]
Nanocoordination polymers	Zn-Quer	Anti-inflammatory and antioxidant properties	Induce cytotoxicity, inhibit angiogenesis, and disrupt molecular pathways related to cell proliferation and invasiveness	MKN-45 cells and mouse model	[55]
P-selectin protein platelet membrane encapsulates SAZ and cisplatin	Cu	Peroxidase	Specifically target cancer cells within aggressive primary tumors and metastatic lymph nodes	MFC cells and mouse models	[64]

Zn-Quer: Zinc-quercetin.