Advanced therapies in patients with inflammatory bowel disease: A nationwide population-based cohort study

doi:10.3748/wjg.121290

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 28, 2026; 32(44): 121290
Published online Nov 28, 2026. doi: 10.3748/wjg.121290

Table 3 Persistency of advanced therapies in adult patients with inflammatory bowel disease after the initiation of first-line therapies, median (Q1-Q3)

Characteristics	Crohn’s disease (n = 6758)	Ulcerative colitis (n = 4447)	P value
Persistency of ATs (days)
Anti-TNF biologics
Infliximab	1037 (422-1875)	516 (154-1324)	< 0.0001
Adalimumab	1135 (511.5-1855.8)	698 (152-1511)	< 0.0001
Golimumab	1435 (1435-1435)¹	257.5 (77-1184.2)	NA
Non-anti-TNF biologics
Vedolizumab	359 (206-567)	281 (110.2-498.2)	0.0057
Ustekinumab	458 (189.8-801)	56 (1-59)	< 0.0001
Small-molecule agent
Tofacitinib		56 (28-378)	NA

¹Only one patient with Crohn’s disease received golimumab; no statistical comparison was performed.

NA: Not applicable for statistical comparison; ATs: Advanced therapies; TNF: Tumor necrosis factor.

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Citation: Choi HI, Moon JR, Lee SH, Cha JM. Advanced therapies in patients with inflammatory bowel disease: A nationwide population-based cohort study. World J Gastroenterol 2026; 32(44): 121290
URL: https://www.wjgnet.com/1007-9327/full/v32/i44/121290.htm
DOI: https://dx.doi.org/10.3748/wjg.121290

Choi HI, Moon JR, Lee SH, Cha JM. Advanced therapies in patients with inflammatory bowel disease: A nationwide population-based cohort study. World J Gastroenterol 2026; 32(44): 121290 [DOI: 10.3748/wjg.121290]

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