Advanced therapies in patients with inflammatory bowel disease: A nationwide population-based cohort study

doi:10.3748/wjg.121290

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Nov 28, 2026; 32(44): 121290
Published online Nov 28, 2026. doi: 10.3748/wjg.121290

Table 2 Use of first-line advanced therapies in patients with inflammatory bowel disease, n (%)

	Crohn’s disease (n = 6758)	Ulcerative colitis (n = 4447)	P value¹
First-line ATs after diagnosis			< 0.0001
Anti-TNF biologics
Infliximab	4400 (65.1)	2485 (55.9)	< 0.0001
Adalimumab	1543 (22.8)	994 (22.4)	0.5560
Golimumab	1 (0.0)	192 (4.3)	< 0.0001
Non-anti-TNF biologics
Vedolizumab	174 (2.5)	595 (13.4)	< 0.0001
Ustekinumab	640 (9.5)	161 (3.6)	< 0.0001
Small-molecule agent
Tofacitinib	0 (0.0)	20 (0.5)	< 0.0001
Days to 1^st line ATs, median (Q1-Q3)
Anti-TNF biologics
Infliximab	167 (14-702)	348 (59-891)	< 0.0001
Adalimumab	273 (49-918.8)	498 (192-1063)	< 0.0001
Golimumab	621 (621-621)²	616.5 (249.2-1186.8)	NA
Non-anti-TNF biologics
Vedolizumab	551 (248-1552)	830.5 (332.8-1731.8)	0.0074
Ustekinumab	651.5 (232.8-1669.5)	997 (507-1855)	0.0057
Small-molecule agent
Tofacitinib		762 (342-1428)	NA

¹The P value for “first-line advanced therapies after diagnosis” represents an overall χ² test for the distribution of advanced therapies types between groups. Individual P values represent comparisons for each specific agent.

²Only one patient with Crohn’s disease received golimumab; no statistical comparison was performed.

NA: Not applicable for statistical comparison; ATs: Advanced therapies; TNF: Tumor necrosis factor.

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Citation: Choi HI, Moon JR, Lee SH, Cha JM. Advanced therapies in patients with inflammatory bowel disease: A nationwide population-based cohort study. World J Gastroenterol 2026; 32(44): 121290
URL: https://www.wjgnet.com/1007-9327/full/v32/i44/121290.htm
DOI: https://dx.doi.org/10.3748/wjg.121290

Choi HI, Moon JR, Lee SH, Cha JM. Advanced therapies in patients with inflammatory bowel disease: A nationwide population-based cohort study. World J Gastroenterol 2026; 32(44): 121290 [DOI: 10.3748/wjg.121290]

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