Advanced therapies in patients with inflammatory bowel disease: A nationwide population-based cohort study

doi:10.3748/wjg.121290

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 28, 2026; 32(44): 121290
Published online Nov 28, 2026. doi: 10.3748/wjg.121290

Table 1 Baseline characteristics of adult patients with newly diagnosed inflammatory bowel disease, mean ± SD/n (%)

Characteristics	Crohn’s disease (n = 16598)	Ulcerative colitis (n = 39737)	P value
Age (years)	30.2 ± 14.6	42.26 ± 16.0	< 0.0001
Age groups			< 0.0001
18-40 years	13060 (78.6)	18543 (46.7)
41-64 years	2846 (17.2)	17416 (43.8)
≥ 65 years	692 (4.2)	3778 (9.5)
Sex (male)	7838 (47.2)	28804 (72.5)	< 0.0001
Type of treatment			< 0.0001
Advanced therapy	6758 (40.7)	4447 (11.2)
Non-advanced therapy	9840 (59.3)	35290 (88.8)
Location of medical institution			< 0.0001
Metropolitan area	6918 (41.7)	14157 (35.6)
Non-metropolitan area	9680 (58.3)	25580 (64.4)
Comorbid disease
Obesity	91 (0.6)	213 (0.5)	0.5855
Pulmonary disease	11091 (66.8)	27818 (69.9)	1.0000
Renal disease	380 (2.3)	1009 (2.5)	0.4213
Liver disease	8549 (51.5)	22469 (56.5)	0.0004
Rheumatic disease	1518 (9.1)	4523 (11.4)	< 0.0001
Diabetes mellitus	1932 (11.6)	8043 (20.2)	< 0.0001
Hypertension	2311 (13.9)	10,840 (27.2)	< 0.0001
Cardiovascular disease	1026 (6.2)	4548 (11.4)	< 0.0001
Any malignancy	736 (4.4)	2648 (6.7)	< 0.0001

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Citation: Choi HI, Moon JR, Lee SH, Cha JM. Advanced therapies in patients with inflammatory bowel disease: A nationwide population-based cohort study. World J Gastroenterol 2026; 32(44): 121290
URL: https://www.wjgnet.com/1007-9327/full/v32/i44/121290.htm
DOI: https://dx.doi.org/10.3748/wjg.121290

Choi HI, Moon JR, Lee SH, Cha JM. Advanced therapies in patients with inflammatory bowel disease: A nationwide population-based cohort study. World J Gastroenterol 2026; 32(44): 121290 [DOI: 10.3748/wjg.121290]

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