FSCN1/ACK1 axis-dependent M2 macrophage polarization fuels colorectal cancer progression

Figure 6 Fascin actin-bundling protein-1 regulates macrophage polarization through activated Cdc42-associated kinase 1. A: Activated Cdc42-associated kinase 1 protein expression; B-E: The mRNA expression levels of M1 and M2 macrophage cytokines; F-H: Protein expression of Inducible nitric oxide synthase and arginase 1. ^bP < 0.01. ^cP < 0.001. FSCN1: Fascin actin-bundling protein-1; TNF-α: Tumor necrosis factor-α; TGF-β1: Transforming growth factor-β1; iNOS: Inducible nitric oxide synthase; Arg1: Arginase 1; ACK1: Activated Cdc42-associated kinase 1; NC: Non-targeting control; ACK1-OE: Activated Cdc42-associated kinase 1 overexpression; CM: Conditioned medium; IL: Interleukin.