FSCN1/ACK1 axis-dependent M2 macrophage polarization fuels colorectal cancer progression

doi:10.3748/wjg.121025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 28, 2026; 32(44): 121025
Published online Nov 28, 2026. doi: 10.3748/wjg.121025

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Figure 4 Fascin actin-bundling protein-1 positively regulates activated Cdc42-associated kinase 1 expression and activated Cdc42-associated kinase 1 promotes malignant phenotype of colon cancer cells. A and B: The mRNA and protein expression levels of activated Cdc42-associated kinase 1 (ACK1) after fascin actin-bundling protein-1 knockdown; C and D: Detection of ACK1 overexpression and knockdown (si-ACK1) efficiency; E: Cell proliferation; F and G: Transwell cell migration and invasion. Scale bar = 200 μm and 100 μm; H: Clone formation experiment. ^cP < 0.001. ACK1: Activated Cdc42-associated kinase 1; FSCN1: Fascin actin-bundling protein-1; ACK1-OE: Activated Cdc42-associated kinase 1 overexpression; NC: Non-targeting control.

Citation: Wang Z, Liu C, Liu H, Jiang Y, Ma Y. FSCN1/ACK1 axis-dependent M2 macrophage polarization fuels colorectal cancer progression. World J Gastroenterol 2026; 32(44): 121025
URL: https://www.wjgnet.com/1007-9327/full/v32/i44/121025.htm
DOI: https://dx.doi.org/10.3748/wjg.121025

Wang Z, Liu C, Liu H, Jiang Y, Ma Y. FSCN1/ACK1 axis-dependent M2 macrophage polarization fuels colorectal cancer progression. World J Gastroenterol 2026; 32(44): 121025 [DOI: 10.3748/wjg.121025]

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