Histologic remission and arrhythmias in patients with inflammatory bowel disease: A nationwide cohort study

Table 2 Characteristics of inflammatory bowel disease patients during periods of clinically active and quiescent inflammatory bowel disease in 2006-2020, n (%)/mean (interquartile range)/mean ± SD

Item	Quiescent IBD	Active IBD	Active IBD in subtypes of IBD
			CD	UC	IBD-U
Number of periods	293289	290860	108625	163417	18818
Number of patients	89114	85763	30092	49061	6610
Number of patients by number of periods
1	30440 (34.2)	28012 (32.7)	9301 (30.9)	16000 (32.6)	2711 (41.0)
2	18002 (20.2)	17135 (20.0)	5765 (19.2)	10007 (20.4)	1363 (20.6)
3	12023 (13.5)	11701 (13.6)	4090 (13.6)	6787 (13.8)	824 (12.5)
≥ 4	28649 (32.2)	28915 (33.7)	10936 (36.3)	16267 (33.2)	1712 (25.9)
Age (years)1
mean ± SD	49.1 ± 18.5	49.4 ± 18.9	48.4 ± 18.9	50.1 ± 18.6	49.5 ± 20.3
Median (IQR)	49.2 (34.0-63.9)	49.7 (34.0-64.4)	48.9 (32.8-63.5)	50.1 (34.9-64.8)	51.3 (31.6-65.9)
< 18	9177 (3.1)	10442 (3.6)	4716 (4.3)	4565 (2.8)	1161 (6.2)
18-40	93218 (31.8)	89971 (30.9)	34371 (31.6)	50145 (30.7)	5455 (29.0)
40-60	97569 (33.3)	95268 (32.8)	35715 (32.9)	54173 (33.2)	5380 (28.6)
≥ 60	93325 (31.8)	95179 (32.7)	33823 (31.1)	54534 (33.4)	6822 (36.3)
Calendar period1
2006-2009	59205 (20.2)	58641 (20.2)	22324 (20.6)	33571 (20.5)	2746 (14.6)
2010-2020	234084 (79.8)	232219 (79.8)	86301 (79.5)	129846 (79.5)	16072 (85.4)
Educational attainment1
0-9 years	57630 (19.7)	58420 (20.1)	22824 (21.0)	31452 (19.3)	4144 (22.0)
10-12 years	134083 (45.7)	131664 (45.3)	49786 (45.8)	73827 (45.2)	8051 (42.8)
≥ 13 years	89008 (30.4)	86096 (29.6)	29736 (27.4)	51397 (31.5)	4963 (26.4)
Missing	12568 (4.3)	14680 (5.1)	6279 (5.8)	6741 (4.1)	1660 (8.8)
IBD duration (years)1
mean ± SD	10.8 ± 10.3	11.1 ± 10.4	11.9 ± 11.2	10.7 ± 9.6	9.9 ± 12.0
Median (IQR)	8.1 (2.4-16.1)	8.4 (2.7-16.5)	8.9 (2.8-18.1)	8.5 (3.0-15.7)	4.8 (0.6-15.1)
0	26271 (9.0)	31739 (10.9)	12445 (11.5)	15632 (9.6)	3662 (19.5)
0-5	81444 (27.8)	70892 (24.4)	24951 (23.0)	40040 (24.5)	5901 (31.4)
> 5	185574 (63.3)	188229 (64.7)	71229 (65.6)	107745 (65.9)	9255 (49.2)
Number of health care visits2
0	61932 (21.1)	63613 (21.9)	22132 (20.4)	37306 (22.8)	4175 (22.2)
1	55308 (18.9)	55407 (19.1)	20357 (18.7)	32021 (19.6)	3029 (16.1)
2-3	71211 (24.3)	70586 (24.3)	25853 (23.8)	40455 (24.8)	4278 (22.7)
≥ 4	104838 (35.8)	101254 (34.8)	40283 (37.1)	53635 (32.8)	7336 (39.0)
Disease history1
Hypertension	48248 (16.5)	46986 (16.2)	16920 (15.6)	26097 (16.0)	3969 (21.1)
Diabetes	20635 (7.0)	20188 (6.9)	6228 (5.7)	12357 (7.6)	1603 (8.5)
Obesity	10753 (3.7)	10531 (3.6)	3982 (3.7)	5671 (3.5)	878 (4.7)
Dyslipidemia	12545 (4.3)	12076 (4.2)	3426 (3.2)	7671 (4.7)	979 (5.2)
Chronic kidney diseases	7353 (2.5)	7400 (2.5)	2937 (2.7)	3831 (2.3)	632 (3.4)
COPD	12405 (4.2)	12488 (4.3)	5020 (4.6)	6369 (3.9)	1099 (5.8)

¹Measured at index date. Index date was defined as date of clinically active or quiescent IBD.

²Measured between 2 years and 6 months before the index date.

CD: Crohn’s disease; COPD: Chronic obstructive pulmonary disease; IBD: Inflammatory bowel disease; IBD-U: Inflammatory bowel disease-unclassified; UC: Ulcerative colitis; IQR: Interquartile range.