Histologic remission and arrhythmias in patients with inflammatory bowel disease: A nationwide cohort study

Table 1 Characteristics of inflammatory bowel disease patients during periods of histologic inflammation and histologic remission in 1969-2017, n (%)/mean (interquartile range)/mean ± SD

Item	Histologic remission	Histologic inflammation	Histologic inflammation in subtypes of IBD
			CD	UC	IBD-U
Number of periods	47462	102904	26168	70962	5774
Number of patients	27779	53719	15021	35678	3020
Number of patients by number of periods
1	17224 (62.0)	30142 (56.1)	8930 (59.5)	19412 (54.4)	1800 (59.6)
2	5927 (21.3)	11806 (22.0)	3436 (22.9)	7775 (21.8)	595 (19.7)
3	2443 (8.8)	5561 (10.4)	1418 (9.4)	3891 (10.9)	252 (8.3)
≥ 4	2185 (7.9)	6210 (11.6)	1237 (8.2)	4600 (12.9)	373 (12.4)
Age (years)1
mean ± SD	45.9 ± 16.6	44.3 ± 17.6	41.3 ± 17.7	45.4 ± 17.4	45.5 ± 18.0
Median (IQR)	46.3 (33.4-58.6)	43.7 (30.5-57.6)	39.9 (26.9-54.8)	44.8 (31.8-58.5)	45.6 (31.0-59.3)
< 18	2319 (4.9)	6011 (5.8)	2300 (8.8)	3345 (4.7)	366 (6.3)
18-40	15345 (32.3)	38169 (37.1)	10836 (41.4)	25417 (35.8)	1916 (33.2)
40-60	19158 (40.4)	36778 (35.7)	8437 (32.2)	26220 (37.0)	2121 (36.7)
≥ 60	10640 (22.4)	21946 (21.3)	4595 (17.6)	15980 (22.5)	1371 (23.7)
Calendar period1
1969-1989	1257 (2.7)	6379 (6.2)	1721 (6.6)	4074 (5.7)	584 (10.1)
1990-2001	7970 (16.8)	29924 (29.1)	7426 (28.4)	20962 (29.5)	1536 (26.6)
2002-2009	15568 (32.8)	32606 (31.7)	8201 (31.3)	23042 (32.5)	1363 (23.6)
2010-2017	22667 (47.8)	33995 (33.0)	8820 (33.7)	22884 (32.3)	2291 (39.7)
Educational attainment1
0-9 years	9182 (19.4)	22003 (21.4)	5701 (21.8)	14995 (21.1)	1307 (22.6)
10-12 years	20606 (43.4)	43549 (42.3)	11217 (42.9)	30001 (42.3)	2331 (40.4)
≥ 13 years	14868 (31.3)	26509 (25.8)	5932 (22.7)	19280 (27.2)	1297 (22.5)
Missing	2806 (5.9)	10843 (10.5)	3318 (12.7)	6686 (9.4)	839 (14.5)
IBD duration (years)1
mean ± SD	9.3 ± 8.6	6.6 ± 8.0	6.5 ± 8.3	6.5 ± 7.7	7.8 ± 9.5
Median (IQR)	7.4 (2.1-13.8)	3.5 (0.0-10.7)	3.1 (0.0-10.6)	3.7 (0.0-10.6)	3.6 (0.0-13.2)
0	1969 (4.2)	28345 (27.6)	7495 (28.6)	19334 (27.3)	1516 (26.3)
0-5	16646 (35.1)	29172 (28.4)	7554 (28.9)	20007 (28.2)	1611 (27.9)
> 5	28847 (60.8)	45387 (44.1)	11119 (42.5)	31621 (44.6)	2647 (45.8)
Number of health care visits2
0	15871 (33.4)	46294 (45.0)	11082 (42.4)	32667 (46.0)	2545 (44.1)
1	10057 (21.2)	20178 (19.6)	4790 (18.3)	14269 (20.1)	1119 (19.4)
2-3	9999 (21.1)	18351 (17.8)	4738 (18.1)	12611 (17.8)	1002 (17.4)
≥ 4	11535 (24.3)	18081 (17.6)	5558 (21.2)	11415 (16.1)	1108 (19.2)
Disease history1
Hypertension	4076 (8.6)	7128 (6.9)	1642 (6.3)	4906 (6.9)	580 (10.1)
Diabetes	2232 (4.7)	4272 (4.2)	839 (3.2)	3092 (4.4)	341 (5.9)
Obesity	810 (1.7)	1357 (1.3)	405 (1.6)	860 (1.2)	92 (1.6)
Dyslipidemia	1195 (2.5)	1728 (1.7)	308 (1.2)	1303 (1.8)	117 (2.0)
Chronic kidney diseases	518 (1.1)	925 (0.9)	259 (1.0)	590 (0.8)	76 (1.3)
COPD	605 (1.3)	1510 (1.5)	379 (1.5)	1008 (1.4)	123 (2.1)

¹Measured at index date. Index date was defined as date of histologic inflammation or remission.

²Measured between 2 years and 6 months before the index date.

CD: Crohn’s disease; COPD: Chronic obstructive pulmonary disease; IBD: Inflammatory bowel disease; IBD-U: Inflammatory bowel disease-unclassified; UC: Ulcerative colitis; IQR: Interquartile range.