Clinicopathological characteristics and survival outcomes of early-onset vs mid-aged gastric cancer using an evidence-based age cutoff

doi:10.3748/wjg.120795

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2026; 32(44): 120795
Published online Nov 28, 2026. doi: 10.3748/wjg.120795

Table 2 Comparison of pathologic results of patients with radical resection, n (%)/mean ± SD

Variables	EOGC (n = 97)	M-GC (n = 503)	P value
pT stage			0.521
T1a	26 (26.80)	126 (25.05)
T1b	23 (23.71)	156 (31.01)
T2	9 (9.28)	54 (10.74)
T3	25 (25.77)	99 (19.68)
T4	14 (14.43)	68 (13.52)
pN stage			0.777
N0	60 (61.86)	325 (64.61)
N1	11 (11.34)	64 (12.72)
N2	10 (10.31)	50 (9.94)
N3	16 (16.49)	64 (12.72)
Tumor size (cm)	4.47 ± 3.23	4.08 ± 2.87	0.228
Number of retrieved LNs	37.79 ± 12.94	35.28 ± 14.20	0.094
Number of metastatic LNs	3.73 ± 10.15	2.66 ± 6.19	0.545
Multiplicity			0.782
Single lesion	94 (96.91)	482 (95.83)
Multiple lesions	3 (3.09)	21 (4.17)
Lauren classification			< 0.001
Intestinal type	25 (25.77)	277 (55.07)
Diffuse type	51 (52.58)	112 (22.27)
Mixed type	15 (15.46)	69 (13.72)
Indeterminate type	6 (6.19)	45 (8.95)
LV invasion	24 (24.74)	177 (35.19)	0.046
PN invasion	33 (34.02)	122 (24.25)	0.044
Extent of omentectomy			0.916
Total omentectomy	37 (38.14)	189 (37.57)
Partial omentectomy	60 (61.86)	314 (62.43)
Postoperative complications			0.242
No	93 (95.88)	482 (95.83)
CDC I	2 (2.06)	3 (0.60)
> CDC II	2 (2.06)	18 (3.58)
In-hospital mortality	0 (0.0)	2 (0.40)	1
Adjuvant CTx	44 (45.36)	153 (30.42)	0.004

EOGC: Early-onset gastric cancer; M-GC: Mid-aged gastric cancer; LV: Lymphovascular; PN: Perineural; CDC: Clavien-Dindo classification; LN: Lymph node; CTx: Chemotherapy.

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Citation: Jeong SA, Lee JB, Kim JH. Clinicopathological characteristics and survival outcomes of early-onset vs mid-aged gastric cancer using an evidence-based age cutoff. World J Gastroenterol 2026; 32(44): 120795
URL: https://www.wjgnet.com/1007-9327/full/v32/i44/120795.htm
DOI: https://dx.doi.org/10.3748/wjg.120795

Jeong SA, Lee JB, Kim JH. Clinicopathological characteristics and survival outcomes of early-onset vs mid-aged gastric cancer using an evidence-based age cutoff. World J Gastroenterol 2026; 32(44): 120795 [DOI: 10.3748/wjg.120795]

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