Clinicopathological characteristics and survival outcomes of early-onset vs mid-aged gastric cancer using an evidence-based age cutoff

doi:10.3748/wjg.120795

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 28, 2026; 32(44): 120795
Published online Nov 28, 2026. doi: 10.3748/wjg.120795

Table 1 Baseline characteristics of study populations, n (%)/mean ± SD

Variables	EOGC (n = 105)	M-GC (n = 532)	P value
Age (year)	44.51 ± 4.25	63.95 ± 7.16	< 0.001
Sex			0.101
Male	70 (66.67)	396 (74.44)
Female	35 (33.33)	136 (25.56)
BMI (kg/m²)	24.22 ± 4.03	23.84 ± 3.69	0.357
Underlying disease	33 (31.43)	308 (57.89)	< 0.001
Previous history of other malignancies	4 (3.81)	42 (7.89)	0.139
CCI score	2.66 ± 1.31	4.50 ± 1.43	< 0.001
Extent of resection			0.369
Subtotal gastrectomy	72 (68.57)	399 (75.00)
Total gastrectomy	26 (24.76)	108 (20.30)
Palliative resection	7 (6.67)	25 (4.70)
pTNM stage			0.290
I	49 (46.67)	298 (56.02)
II	24 (22.86)	104 (19.55)
III	24 (22.86)	105 (19.74)
IV	8 (7.62)	25 (4.70)

EOGC: Early-onset gastric cancer; M-GC: Mid-aged gastric cancer; BMI: Body mass index; CCI: Charlson comorbidity index; pTNM: Pathological tumor node metastasis.

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Citation: Jeong SA, Lee JB, Kim JH. Clinicopathological characteristics and survival outcomes of early-onset vs mid-aged gastric cancer using an evidence-based age cutoff. World J Gastroenterol 2026; 32(44): 120795
URL: https://www.wjgnet.com/1007-9327/full/v32/i44/120795.htm
DOI: https://dx.doi.org/10.3748/wjg.120795

Jeong SA, Lee JB, Kim JH. Clinicopathological characteristics and survival outcomes of early-onset vs mid-aged gastric cancer using an evidence-based age cutoff. World J Gastroenterol 2026; 32(44): 120795 [DOI: 10.3748/wjg.120795]

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