Emodin ameliorates cholestatic liver injury by regulating bile acid metabolism and gut microbiota in mice

Figure 11  Fecal microbiota transplantation of emodin-fed mice modulated gut microbiota. A: Bacterial community composition at the phylum level; B: Bacterial community composition at the genus level; C: Principal co-ordinates analysis of the gut microbiota in each group at the genus level; D: STAMP analysis uncovered the differences between F-control and F-α-naphthylisothiocyanate (ANIT) groups, F-ANIT and F-emodin-ANIT groups (the P value < 0.05 for declaring significance); E-H: Relative abundance of differential microbiota. Data were analyzed via two-sided Welch’s t-test, n = 5. ^aP < 0.05 vs control group, ^bP < 0.05 vs α-naphthylisothiocyanate group. Cont: Control; Emo: Emodin; ANIT: Α-naphthylisothiocyanate; PCoA: Principal co-ordinates analysis.